Parenteral Manual


Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Recominant Human Monoclonal antibody
Original Date: 
February 2012
  •  Currently undergoing Phase 1 trials for the treatment of high-risk rhabomyosarcoma, refractory solid tumours and Ewing sarcoma in pediatrics

  • Currently undergoing Phase 2 trials for the treatment of metastatic colorectal cancer, hormone-refractory breast cancer, castration-refractory prostate cancer, cancer of the head and neck and soft tissue sarcoma

Reconstitution and Stability: 
  • Available as a 250 mg single-use vial in 5 mg/mL concentration

  • Store unopened vials in refrigerator (2° - 8ºC). Do not freeze.

  • Protect from light

  • For patients < 20 kg: solution can be administered undiluted if volume > 125 mL.  For doses with a volume < 125 mL, further dilute to 125 mL with 0.9% NaCl

  •    For patients > 20 kg: solution can be administered undiluted if volume > 250 mL. For doses with a volume < 250 mL, further dilute to 250 mL with 0.9% NaCl

  •          Do not mix lot numbers when preparing the solution for administration

  •         Stable 24 hours refrigerated or at room temperature once mixed in a minibag.

  •  Solutions compatible: Normal Saline

  • DO NOT mix with other medications    


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Direct NO
IV Intermittent Infusion YES - Infuse over 1 hour or at a rate not to exceed 25 mg/min
- Administer via PVC or non-PVC tubing with a 0.22 micron in-line low-protein binding filter
- Infusion sets should be flushed thoroughly with 0.9% NaCl prior to use
IV Continuous Infusion NO

(For neonatal dosages, refer to Neonatal IV Drug Manual.)


  •  Investigational use: Children’s Oncology Group protocol ARST08P1
  • 3 - 9 mg/kg IV once weekly


  • 3 - 15 mg/kg IV once every 2 weeks to once weekly





Potential hazards of parenteral administration: 

Immediate (within a few minutes to hours):

  • Infusion-related reaction – transient flushing, rash, drug fever, urticaria, dyspnea, bronchospasm
  • Anaphylaxis
  • Fatigue
  • Nausea & vomiting, diarrhea

Delayed (within a few days or weeks):

  • Hyperglycemia (may require treatment)
  • Sensorineural hearing loss
  • Back pain
  • ·          Thrombocytopenia, lymphopenia
  • ·          Anorexia
  • ·          Arthralgia

The information contained on this website is provided for informational purposes only, as a guide to assist physicians, nurses and other healthcare providers in deciding on the appropriate care required for a particular patient. At all times, physicians, nurses and other healthcare providers must exercise their independent clinical judgment, based on their knowledge, training and experience, taking into account the specific facts and circumstances of each patient, when deciding on the appropriate course of investigation and/or treatment to recommend in a particular clinical situation.

CHEO has made every effort to ensure that the information contained on this website is as current and accurate as possible. However, changes can occur due to ongoing research and the constant influx of new information. Where possible, hospitals and healthcare practitioners should verify the information before acting on it.

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