Parenteral Manual


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Alternate Name(s): 
HALAVEN, IND #122686,E7389
Antineoplastic - CYTOTOXIC
Original Date: 
September 2014
  • Children:  Investigational in children greater than or equal to 12 years of age for recurrent or refractory osteosarcoma
  • Adults:  Approved for use in metastatic breast cancer
Reconstitution and Stability: 
  • single-use vial containing 0.5 mg/mL (1 mg in 2 mL vial);  clear, colourless solution
  • store in original container at room temperature
  • undiluted drug is stable in a polypropylene syringe for 4 hours at room temperature and 24 hours in the refrigerator
  • concentrations between 0.005 mg/mL and 0.2 mg/mL in 0.9% sodium chloride stable in syringe or polypropylene/polyethylene bags for 48 hous at room temperature or in the refrigerator
  • 0.9% sodium chloride ONLY
  • DO NOT mix with any other drugs
  • INCOMPATIBLE with Dextrose

(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Direct YES - over 2 to 5 minutes
IV Intermittent Infusion NO
IV Continuous Infusion NO

(For neonatal dosages, refer to Neonatal IV Drug Manual.)

Children:  (greater than or equal to 12 years of age):  1.4 mg/m2 IV days 1 and 8 of each 21 day cycle; refer to protocol for any dose modifications

Adult:  same as above

Dose adjustment required for liver and kidney impairment.  Refer to specific protocol and standard references

Potential hazards of parenteral administration: 

Extravasation risk:  not a vesicant

Immediate  (within a few minutes or hours):
-  nausea, vomiting (low emetogenicity), hypersensitivity

Early  (within a few days or weeks, prior to next cycle):
-  likely (greater than 20%) - neutropenia, thrombocytopenis, anemia, alopecia, fatigue, constipation, weight loss, transaminitis
-  less likely ( less than or equal to 20%) - abnormal electrolytes, abdominal pain, diarrhea, dry mouth, fever, headache, mucositis, myalgia, periperal motor and/or sensory neuropathy, prolonged QTc interval

Treatment for unusual side effects are available through the study chair identified on the front page of the protocol and/or pharmacy

  • extensively metabolized by CYP 3A4 but does not significantly inhibit or induce CYP 3A4 activity.  No drug - drug interactions are expected with CYP 3A4 inhibitors or inducers
    -  hypersensitivity to Eribulin or any of its excipients;  concurrent serious or uncontrolled infection
    -  medications that prolong QTc interval are prohibited ( e.g. macrolide anibiotics, domperidone, pentamidine, phenothiazines);  if possible, avoid medications that may prolong QTc (e.g. ondansetron, granisetron, some quinolones, voriconazole, famotidine)

Children's Oncology Group protocol AOST1322 (August 12, 2014 version)

Eribulin Monograph, Cancer Care Ontario website:  accessed September 25, 2014

Eribulin Monograph, Lexi-Comp on-line, accessed September 25, 2014

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