Parenteral Manual

Alemtuzumab (Non-Formulary)

Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
MabCampath, Campath
Monoclonal antibody, immunosuppressant
Original Date: 
January 2020
  • B-cell chronic lymphocytic leukemia (B-CLL)
  • Experimental use for the prophylaxis of graft versus host disease (GVHD) in stem cell transplant, and for refractory hemophagocytic lymphohistiocytosis (HLH)
Reconstitution and Stability: 
  • Supplied as a 1 mL single-use vial containing 30 mg of alemtuzumab
  • Refrigerate unused vials
  • DO NOT SHAKE the vial or prepared product
  • Dilute in 100 mL of 0.9%NaCl or D5W. GENTLY INVERT the bag to mix the solution.
  • Diluted solution stable for 8 hours at room temperature or refrigerated
  • Protect from light
  • Solution Compatible: 0.9%NaCl, D5W
  • Do not mix with any other drugs or solutions

(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

SC Yes
IV direct No
IV intermittent infusion

Yes, preferred

Usual concentration < 0.3 mg/mL

Infuse over 2-6 hours

IV continuous infusion No



(For neonatal dosages, refer to Neonatal IV Drug Manual.)


  • HLH: 1 mg/kg total, divided over 4-6 days with initial dose of 0.06 mg/kg (max= 3 mg) followed by a daily dose escalating schedule


  • B-CLL: initial: 3 mg IV daily until tolerated, then escalate to 10 mg until tolerated, then escalate to the maintenance dose of 30 mg IV three times weekly on alternate days
Potential hazards of parenteral administration: 
  • Infusion reactions:
    • Premedication with an oral antihistamine and acetaminophen prior to each dose, and close monitoring highly recommended.  Corticosteroids may be used in addition to an antihistamine and acetaminophen
    • Infusion reaction may include: pyrexia, chills/rigors, nausea, hypotension, urticaria, dyspnea, rash, emesis, bronchospasm
      • Meperidine may be used to treat rigors
    • For severe infusion related symptoms, stop alemtuzumab infusion and administer hydrocortisone
    • For persistent acute infusion reactions, infusion time may be extended to up to 8 hours from the time of dose preparation
  • Alemtuzumab is not a vesicant

- Lexicomp. Alemtuzumab Product Monograph. Accessed 28Jan2020

- Sanofi Genzyme. MabCampath Product Monograph. Accessed 28Jan2020.

- BC Cancer Chemotherapy Preparation and Stability Chart v2. Accessed 28Jan2020.

- Marsh et al. Salvage Therapy of Refractory Hemophagocytic Lymphohistiocytosis with Alemtuzumab. Pediatr Blood Cancer. 2013 Jan; 60(1): 101-109

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