Parenteral Manual

Tpn/lipid Y-Site Compatibility

Updated September 16, 2014 - 9:10am

 

 

 

 

DRUG NAME

PN

LIPID

COMMENTS

Acyclovir

I

I

Visual precipitate forms

Albumin

C

I

 

Amikacin

C

I

Causes oiling out of fat emulsion

Aminophylline

C,I

C,I

Caution with high concentration of Ca/Phos

Amiodarone

--

--

 

Amphotericin B

I

I

Formation of fine yellow particles

Ampicillin

I

I

 

Atracurium

C

--

 

 

 

 

 

Carboplatin

C

C

 

Cefazolin

C

C

 

Cefotaxime

C

C

 

Ceftazidime

C

C

 

Ceftriaxone

C

C

 

Cefuroxime

C

C

 

Chlorpromazine

C

C

TPN must not contain ranitidine

Ciprofloxacin

C

C

 

Clindamycin

C

C

 

Cloxacillin

C

I

 

Clotrimoxizole

I

--

Precipiate forms

Cyclosporine

I

I

 

Cytarabine

C

C

 

 

 

 

 

Dexamethasone

C

C

 

Digoxin

C

C

 

Diphenhydramine

C

C

 

Dobutamine

C

C

 

Dopamine

C

I

 

Doxycycline

C

I

 

 

 

 

 

Enalaprilat

C

C

 

Epinephrine

C

--

 

Erythromycin

C

C

 

 

 

 

 

Fentanyl

C

C

 

Filgrstim (G-CSF)

I

I

 

Fluconazole

C

C

 

Fluorouracil

C

C

 

Folic acid

C

C

 

Furosemide

C

C

 

 

 

 

 

Gancyclovir

I

I

Precipitate forms

Gentamicin

C

C

 

Granisetron

C

C

 

 

 

 

 

Heparin

C

I

 

Hydralazine

--

--

 

Hydrocortisone Na succinate

C

C

 

Hydromorphone

C

I

 

Hydroxyzine

C

C

 

 

 

 

 

Ifosfamide

C

C

 

Imipenem-cilastatin

C

C

 

Insulin

C

C

TPN must not contain ranitidine

Isoproterenol

C

C

 

 

 

 

 

Lidocaine

C

C

 

Lorazepam

C

I

 

 

 

 

 

Magnesium sulfate

C

C

 

Mannitol

C

C

 

Meperidine

C

C

 

Meropenum

C

C

 

Methylprenisolone Na succinate

C

C

 

Metoclopramide

C

C

 

Metronidazole

C

C

 

Midazolam

I

I

Precipitate forms

Milrinone

C

--

 

Mitoxantrone

I

I

 

Morphine

C

C

If morphine < 1 mg/mL

 

 

 

 

Nitroglycerin

C

C

 

Nitroprusside

I

I

 

Norepinephrine

C

C

 

 

 

 

 

Octreotide

C

C

 

Ondansetron

C

I

 

 

 

 

 

Penicillin G sodium

C

C

 

Phenobarbitol

C

I

PN must not contain ranitidine

Phenytoin

I

I

Immediate precipitate

Phytonadione

C

C

 

Piperacillin

C

C

 

Potassium chloride

C

C

 

Potassium phosphate

I

I

Dependant on concentration. Contact pharmacy

Prochlorperazine

C

C

 

 

 

 

 

Ranitidine

C

C

 

 

 

 

 

Sodium bicarbonate

I

I

Incompatible with many electrolytes.  Precipitate forms

 

 

 

 

Tacrolimus

C

C

 

Tazocin

C

C

 

Thiamine

C

C

 

Ticarcillin

C

C

 

Tobramycin

C

C

 

 

 

 

 

Vancomycin

C

C

 

Legend:  C = Compatible; I = Incompatible; -- = Data Unclear

For drugs not listed or any other compatibility questions, please call Pharmacy

For drugs not listed or any other compatibility questions, please call Pharmacy

Note: in the parenteral manual monographs, compatibility with parenteral nutrition is indicated as TPN, amino acids/dextrose and/or lipids

TPN: refers to amino acids, dextrose and fat emulsion. 
- If a drug is stated compatible in TPN, it is compatible with all 3 components
- If a drug is only compatible with certain components, it is stated as such: fat emulsion or amino acids/dextrose

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