Neonatal Drug Therapy Manual

Updates

October 2024: sildenafil (updated dosing section)

September 2024: pneumococcal vaccine (new product); nirsevimab (new product); Omegaven® (new monograph)

July 2024: cosyntropin (updated dosing); Fentanyl & Ketamine (added MIST protocol dosing); fluconazole (updated prophylaxis dosing)

June 2024: phenylephrine (updated reconstitution instructions); norepinephrine, milrinone, dobutamine, dopamine, epinephrine, vasopressin (added guidance on titrations).

May 2024: dexmedetomidine (updated monograph in general).

March 2024: alprostadil E1/PGE 1 (updated dosing range info); alteplase (vial does not need filtering anymore); SMOF and Milrinone (new compatibility info for < 200 mcg/mL)

February 2024: Atropine and Succinylcholine (added IV direct infusion time info); Dobutamine, Dopamine, Epinephrine, Milrinone, Norepinephrine, Vasopressin (updated and refined dosing for hypotension); Dextrose 40% Oral Gel (new)

December 2023: Sodium Bicarbonate (added info for 4.2% backorder); caffeine and insulin (compat info with SMOF)

November 2023: ferrous sulfate (iron)- updated dosing and monitoring. Ketamine (added MIST Protocol, updated info on recommended rate of administration). Palivizumab [Synagis] (protect from light). Ampicillin (added IM preparation info for TOH).

October 2023: caffeine (updated TOH administration info)

September 2023: Pantoprazole (added IV direct info)

August 2023: Vitamin K (updated dosing section and notes)

June 2023: Fluconazole (updated dosing); Norepinephrine (titration info)

April 2023: Gabapentin (new)

March 2023: Metoclopramide (new)

Feb 2023: Acetaminophen (added Cheo Post-Operative Pain & Sedation Guideline dosing info), Cosyntropin and Aldactazide (updated test interaction info)

Nov 2022: Erythromycin (new dosing/indication info), Octreotide (new), Succinylcholine (updated ADR info)

Oct 2022: Loperamide (new)

Sept 2022: Tobramycin and Gentamicin (new dosing recommendations), Ammonul® (Sodium Phenylacetate and Sodium Benzoate) (new), Arginine HCL (new)

August 2022: Ampicillin (updated compatibility info), Ketamine (updated TOH concentration info), Cefazolin (new dosing recommendations), Vasopressin (new cheo concentration), Ceftriaxone sodium (new), Cefotaxime (new indication and dose added), Rotavirus Vaccine (updated max age for final doses)

July 2022: Insulin (clarified priming/flush instructions)

June 2022: Cyclomydril® (cyclopentolate hydrochloride and phenylephrine hydrochloride), Ursodiol (new)

May 2022: Insulin (added neonate hyperkalemia treatment info), Nitroglycerin topical (new), Epinephrine (new NRP guidelines)

April 2022: Epinephrine Inhalation (new), Fentanyl/Midazolam/Morphine (new Palliative Care Dosing)

March 2022: Hydrochlorothiazide (new), Cephalexin (new UTI prophylaxis dosing), Penicillin G (updated vial sizes)

November 2021: Ketamine & Heparin (compatibility info), Ketamine & Midazolam (compatability info), Hyaluronidase

July 2021: Atropine, Fentanyl, Ketamine, Midazolam, Morphine, Sucrose

June 2021: Penicillin G

March 2021: Diazoxide

February 2021: Dexamethasone, Ibuprofen, Propranolol, Sotalol

December 2020: Acetaminophen, Amikacin, Dexamethasone, Gentamicin, Glucagon, Hyaluronidase, Levetiracetam, Rotavirus Live Oral Vaccine, Sotalol, Tobramycin, Vancomycin

November 2020: Lamivudine, Nevirapine, Rotavirus Live Oral Vaccine, Zidovudine,

September 2020: Cephalexin, Cloxacillin

July 2020: Caffeine, Cloxacillin

May 2020: Cosyntropin, Ketamine, Rotavirus vaccine

March 2020: Acetaminophen, Dexmedetomidine

February 2020: Caffeine, Diazoxide, Fentanyl, Piperaciilin/Tazobactam

November 2019: Amlodipine, Cephalexin, Ibuprofen, Indomethacin, Methotrimeprazine

September 2019: Probiotics, Rotavirus Pentavalent Live Oral Vaccine, Vasopressin

July 2019: Metronidazole

June 2019: Calcium gluconate

May 2019: Hydrocortisone

April 2019: Dexmedetomidine, Vitamin K

February 2019: Cyclopentolate/Phenylephrine

January 2019: Ampicillin, Epinephrine Racemic 2.25%

November 2018: Heparin, Oseltamivir

October 2018: Ampicillin

September 2018: Cefazolin, Gentamicin, Pneumococcal Conjugate Vaccine, Tobramycin

June 2018: Salbutamol

March 2018: Acetazolamide

February 2018: Methotrimeprazine, Methylprednisolone

January 2018: Fluconazole, Furosemide, Morphine, Oseltamivir, Sulfamethoxazole/Trimethoprim

December 2017: Albumin, Gentamicin, Intravenous Immune Globulin, Tobramycin

November 2017: Calcium gluconate, Lorazepam, Midazolam

October 2017: Cefotaxime, Cephalexin, Diazoxide, Fentanyl, Ibuprofen, Indomethacin, Zidovudine

September 2017: Cefazolin, Dexamethasone, IVIG, Propafenone

August 2017: Epinephrine, Morphine, Vancomycin

July 2017 - Lorazepam

June 2017 - Fentanyl

April 2017 - Amikacin, Cefazolin, Cefotaxime, Ceftazidime, Cefuroxime, Clindamycin, Dexamethasone, Enoxaparin, Gentamicin, Levetiracetam, Metronidazole, Milrinone, Pantoprazole, Penicillin G, Piperacillin, Piperacillin/Tazobactam, Ranitidine, Tobramycin

March 2017 - Fentanyl, Paraldehyde (deleted)

February 2017 - Methotrimeprazine

January 2017 - Diazoxide, Hydrocortisone, Hydromorphone, Phentolamine

December 2016 - Azithromycin, Calcium gluconate, Phenytoin, Vitamin K 

October 2016 - Tromethamine (deleted)

September 2016 - Vasopressin

August 2016 - Cefazolin, Clonidine, Meropenem

May 2016 - Levetiracetam, Lidocaine, Norepinephrine

April 2016 - Gentamicin, Tobramycin

March 2016 - Ibuprofen, Levothyroxine

February 2016 - Morphine, Phenobarbital, Valganciclovir

January 2016 - Clonidine

December 2015 - Fluconazole, Pantoprazole

November 2015 - Acetaminophen

October 2015 - Dextrose solutions, Diazoxide, Probiotics (Flora Baby)

September 2015 - Midazolam, Milrinone, Pyridoxine, Vasopressin

July 2015 - Sucrose

June 2015 - Caffeine, Calcium gluconate, Flora Baby Probiotics, Insulin

April 2015 - Acetaminophen, Calcium gluconate, Famotidine

March 2015 - Dexamethasone, Indomethacin

February 2015 - Ganciclovir, Hydralazine

January 2015 - Heparin, Tobramycin

December 2014 - Gentamicin, Tobramycin, Vancomycin

November 2014 - Calcium Gluconate, Fentanyl

October 2014 - Caffeine, Vancomycin

July 2014 - Vancomycin

June 2014 - Ampicillin, Calcium gluconate, Flecainide, Fluconazole, Glucagon, Morphine

May 2014 - Fentanyl, Procainamide, Sildenafil, Sodium bicarbonate

February 2014 - Calcium - Phosphate - Vitamin D

January 2014 - Isoproterenol - Propranolol

December 2013 - Phenobarbital

October 2013 - Fluconazole

September 2013 - Diazoxide - Hydrocortisone - Miscellaneous IV Solutions - Phentolamine

June 2013 - Dexamethasone - Enoxaparin - Hydrocortisone - Ibuprofen - Indomethacin - Morphine

May 2013 - Alteplase

April 2013 - Calcium Gluconate - Magnesium Sulfate - Sotalol - Tobramycin

March 2013 - Propranolol

February 2013 - Gentamicin

January 2013 - Vancomycin

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The information contained on this website is provided for informational purposes only, as a guide to assist physicians, nurses and other healthcare providers in deciding on the appropriate care required for a particular patient. At all times, physicians, nurses and other healthcare providers must exercise their independent clinical judgment, based on their knowledge, training and experience, taking into account the specific facts and circumstances of each patient, when deciding on the appropriate course of investigation and/or treatment to recommend in a particular clinical situation.

CHEO has made every effort to ensure that the information contained on this website is as current and accurate as possible. However, changes can occur due to ongoing research and the constant influx of new information. Where possible, hospitals and healthcare practitioners should verify the information before acting on it.

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