Parenteral Manual


Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Histamine H2 receptor antagonist
Original Date: 
March 2012
Revised Date: 
December 2019
  • Treatment and prophylaxis of duodenal ulcer,benign gastric ulcer
  • Treatment of gastroesophageal reflux disease (GERD)
Reconstitution and Stability: 
  • Available as 10 mg/mL solution
  • Protect from light.  Store in refrigerator
  • Multidose vial stable for 28 days refrigerated after puncture

- Solutions Compatible:  dextrose solutions up to D10W, 0.9% NaCl, Lactated Ringer's , TPN (amino acids/dextrose)

- Additive/ Above Cassette compatible:  cefazolin, flumazenil, vancomycin

- Y-site compatible:  ampicillin, cefotaxime, cefuroxime, dexamethasone, gentamicin, heparin, insulin, magnesium, midazolam, morphine, ondansetron, potassium chloride, sodium bicarbonate

- Incompatible:  azithromycin, piperacillin-tazobactam


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Direct YES
Usual dilution:  0.5 mg/mL
Infusion time:  greater than 2 minutes
Infusion rate not to exceed 10 mg/minute
IV Intermittent Infusion YES
Usual dilution:  0.5 mg/mL
Infuion time:  15 - 30 minutes
IV Continuous Infusion YES
Daily dose may be added to TPN

(For neonatal dosages, refer to Neonatal IV Drug Manual.)


Infants greater than or equal to 3 months to 1 year:

     - 0.25 - 0.5 mg/kg/dose once daily

1 - 16 years:

  • 0.25 mg/kg/dose IV Q12H  (Maximum dose:  20 mg/dose, 40 mg/day)
  • Doses of up to 0.5 mg/kg/dose have been used in clinical studies


  • 20 mg/dose IV Q12H
  • Maximum 40 mg/day


  • CrCl 30 - 50 mL/minute:  administer 0.5 mg/kg Q24H
  • CrCl 10 - 29 mL/minute:  administer 0.25 mg/kg Q24H
  • Cr Cl < 10 mL/minute:  administer 0.125 mg/kg Q24H
Potential hazards of parenteral administration: 
  • Headache, dizziness, constipation, diarrhea

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