Parenteral Manual

Estrogen, Conjugated

Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Estrogen, Premarin
Original Date: 
March 6, 2006
  • Short term use to control abnormal uterine bleeding
Reconstitution and Stability: 
  • Available in 25 mg vials.
  • Store vials in the refrigerator
  • Reconstitute vials with 5 mL of sterile water for injection. Add diluent slowly, letting it flow against the side of the vial. Mix solution gently; avoiding vigorous shaking.
  • Reconstituted solution stable 60 days in refrigerator

- Solutions Compatible: dextrose up to D10W, 0.9% NaCl

- Additives/Above Cassette Compatible: no information

- Y-site Compatible: heparin, KCl (up to 40 mmol/L)

- Incompatible: acidic solutions (ringer's solution, ringer's lactate, protein hydrolysate, ascorbic acid)


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IM Yes, IV is preferred because of faster onset of action
IV Push


Infusion rate: no faster than 5 mg/minute

IV Intermittent NO
IV Continuous Infusion NO

(For neonatal dosages, refer to Neonatal IV Drug Manual.)


  • 2.5 - 5 mg IM/IV every 4-6 hours until response


  • 25 mg IM/IV
  • then initiate cyclical oral therapy
  • IM/IV dose can be repeated in 6-12 hours if necessary
Potential hazards of parenteral administration: 
  • nausea, vomiting or flushing with rapid injection
  • hypertension
  • headache
  • jaundice
  • increased sodium and water retention
  • Monitor blood pressure, serum glucose, serum calcium, liver enzymes
  • Monitor hematocrit, hemoglobin and PTT
  • Use with caution in patients with impaired liver function, renal insufficiency or metastatic carcinoma and bone disease

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