Alternate Name(s):
Estrogen, Premarin
Classification:
Hormone
Original Date:
March 6, 2006
Indications:
- Short term use to control abnormal uterine bleeding
Reconstitution and Stability:
- Available in 25 mg vials.
- Store vials in the refrigerator
- Reconstitute vials with 5 mL of sterile water for injection. Add diluent slowly, letting it flow against the side of the vial. Mix solution gently; avoiding vigorous shaking.
- Reconstituted solution stable 60 days in refrigerator
Compatibility:
- Solutions Compatible: dextrose up to D10W, 0.9% NaCl
- Additives/Above Cassette Compatible: no information
- Y-site Compatible: heparin, KCl (up to 40 mmol/L)
- Incompatible: acidic solutions (ringer's solution, ringer's lactate, protein hydrolysate, ascorbic acid)
Administration:
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
| SC | NO |
| IM | Yes, IV is preferred because of faster onset of action |
| IV Push |
YES Infusion rate: no faster than 5 mg/minute |
| IV Intermittent | NO |
| IV Continuous Infusion | NO |
Dosage:
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
Pediatric:
- 2.5 - 5 mg IM/IV every 4-6 hours until response
Adult:
- 25 mg IM/IV
- then initiate cyclical oral therapy
- IM/IV dose can be repeated in 6-12 hours if necessary
Potential hazards of parenteral administration:
- nausea, vomiting or flushing with rapid injection
- hypertension
- headache
- jaundice
- increased sodium and water retention
Notes:
- Monitor blood pressure, serum glucose, serum calcium, liver enzymes
- Monitor hematocrit, hemoglobin and PTT
- Use with caution in patients with impaired liver function, renal insufficiency or metastatic carcinoma and bone disease