Parenteral Manual


Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Original Date: 
August 2005
Revised Date: 
September 2011
  • Treatment of ventricular arrhythmias
Reconstitution and Stability: 
  • Available as a 3.5 mg/mL injection
  • Propafenone 1 mg/mL  is stable for 48 hours at 21-23°C in D5W when stored in polypropylene syringes or PVC bags.

- Solutions Compatible: D5W ONLY

- Additive/buretrol Compatible: amiodarone, dopamine, lidocaine

- Y-site Compatible: no information

- Incompatible: heparin, nitroprusside, NS


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Direct


IV Intermittent Infusion


Usual dilution: 1 mg/mL

Infusion time: 2 hours

IV Continuous Infusion


Usual dilution: 1 mg/mL

Click here to access SDC Drug Infusion Sheet


(For neonatal dosages, refer to Neonatal IV Drug Manual.)


  • IV load: 2 mg/kg over 2 hours
  • IV infusion: 4-7 mcg/kg/minute
  • Decrease dose if QRS complex > 0.12 seconds or PR interval >0.24 seconds

- Ventricular Tachycardia:

  • 2 mg/kg IV push, followed by 2 mg/minute by IV infusion

- Ventricular Arrhythmias:

  • 1-2.5 mg/kg IV
Potential hazards of parenteral administration: 
  • Hypotension with rapid administration
  • Tremor
  • Bradycardia, hypotension, arrhythmia
  • Anemia, thrombocytopenia, agranulocytosis
  • Bitter taste, vomiting, abdominal pain
  • May increase serum digoxin levels
  • Monitor blood pressure and heart rate

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