Propafenone (SPECIAL ACCESS PROGRAM)
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- Treatment of ventricular arrhythmias
Reconstitution and Stability:
- Available as a 3.5 mg/mL injection
- Propafenone 1 mg/mL is stable for 48 hours at 21-23°C in D5W when stored in polypropylene syringes or PVC bags.
- Solutions Compatible: D5W ONLY
- Additive/buretrol Compatible: amiodarone, dopamine, lidocaine
- Y-site Compatible: no information
- Incompatible: heparin, nitroprusside, NS
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
|IV Intermittent Infusion
Usual dilution: 1 mg/mL
Infusion time: 2 hours
|IV Continuous Infusion
Usual dilution: 1 mg/mL
Click here to access SDC Drug Infusion Sheet
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
- IV load: 2 mg/kg over 2 hours
- IV infusion: 4-7 mcg/kg/minute
- Decrease dose if QRS complex > 0.12 seconds or PR interval >0.24 seconds
- Ventricular Tachycardia:
- 2 mg/kg IV push, followed by 2 mg/minute by IV infusion
- Ventricular Arrhythmias:
Potential hazards of parenteral administration:
- Hypotension with rapid administration
- Bradycardia, hypotension, arrhythmia
- Anemia, thrombocytopenia, agranulocytosis
- Bitter taste, vomiting, abdominal pain
- May increase serum digoxin levels
- Monitor blood pressure and heart rate
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