Classification:
Antiarrhythmic
Original Date:
August 2005
Revised Date:
September 2011
Indications:
- Treatment of ventricular arrhythmias
Reconstitution and Stability:
- Available as a 3.5 mg/mL injection
- Propafenone 1 mg/mL is stable for 48 hours at 21-23°C in D5W when stored in polypropylene syringes or PVC bags.
Compatibility:
- Solutions Compatible: D5W ONLY
- Additive/buretrol Compatible: amiodarone, dopamine, lidocaine
- Y-site Compatible: no information
- Incompatible: heparin, nitroprusside, NS
Administration:
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
| SC | NO |
| IM | NO |
| IV Direct |
NO |
| IV Intermittent Infusion |
Yes Usual dilution: 1 mg/mL Infusion time: 2 hours |
| IV Continuous Infusion |
Yes Usual dilution: 1 mg/mL |
Click here to access SDC Drug Infusion Sheet
Dosage:
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
Pediatric:
- IV load: 2 mg/kg over 2 hours
- IV infusion: 4-7 mcg/kg/minute
- Decrease dose if QRS complex > 0.12 seconds or PR interval >0.24 seconds
Adult:
- Ventricular Tachycardia:
- 2 mg/kg IV push, followed by 2 mg/minute by IV infusion
- Ventricular Arrhythmias:
- 1-2.5 mg/kg IV
Potential hazards of parenteral administration:
- Hypotension with rapid administration
- Tremor
- Bradycardia, hypotension, arrhythmia
- Anemia, thrombocytopenia, agranulocytosis
- Bitter taste, vomiting, abdominal pain
Notes:
- May increase serum digoxin levels
- Monitor blood pressure and heart rate