Parenteral Manual

Rivipansel (STUDY DRUG)

Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Pan-selectin antagonist
Original Date: 
November 2016
Revised Date: 
March 2017
  • Treatment of Vaso-occlusive crisis (VOC) of sickle cell disease (SCD)


Reconstitution and Stability: 
  • Supplied as 30 mg/mL solution
  • Store in refrigerator
  • Administration must be completed within 24 hours of initiation of dose preparation - with a maximum of 6 hours of the storage period at room temperature (15 - 25˚C) and the remainder must be under refrigeration (2 – 8 ˚C).
  • The 6 hours at room temperature must account for preparation, transfer time to the inpatient unit and infusion time

-  Solution Compatibility :  D5W, 0.9% NaCl, dextrose-saline combinations

-  Additive/Above Cassette Compatible:  No information

-  Y- site Compatible:  up to 20 mEq/L KCl


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Push NO
IV Intermittent Infusion

Usual dilution:  undiluted (30 mg/mL)
Infusion time: drug and flush over 30 minutes

- using a  0.22 micron inline filter and line supplied by pharmacy

IV Continuous Infusion NO



(For neonatal dosages, refer to Neonatal IV Drug Manual.)

Subject Age and Weight Loading Dose Maintenance Dose
  •  6 - 11 years and any weight or
  • 12 years and older and weight less than or equal to 40 kg
40 mg/kg
MAX: 1680 mg
20 mg/kg
MAX: 840 mg Q12H
 ± 2 hours
  • 12 years and older and weight greater than 40 kg
1680 mg 840 mg Q12H
 ± 2 hours


Potential hazards of parenteral administration: 
  • Upper abdominal pain
  • Infusion site irritation
  • Dizziness
  • Headache
  • Dysmenorrhoea
  • Protocol Number:  B5201002, Amendment 1, 20 March 2015
    A Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of Rivipansel (GMI-1070)  in the treatment of vaso-occlusive crisis in hospitalized subjects with sickle cell disease

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