Parenteral Manual

Zinc sulfate

Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Trace metal supplement
Original Date: 
August 2005
Revised Date: 
December 2019
  • Treatment or prevention of zinc deficiency                       
  • Intended for use as an additive to total parenteral nutrition solutions
Reconstitution and Stability: 
  • Available as a 5 mg/mL solution
  • Stable at room temperature                                  
  • Stable for 24 hours when diluted in TPN

- Additive/buretrol Compatible: TPN (amino acids/dextrose)


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Direct NO
IV Intermittent Infusion NO
IV Continuous Infusion YES, intended for use as an additive to TPN

(For neonatal dosages, refer to Neonatal IV Drug Manual.)

In terms of elemental zinc

  • <3 months:   300 mcg/kg/day
  • >3 months - <5 years:   100 mcg/kg/day   (maximum: 5 mg/day)
  • >5 years:  2.5-5 mg/day
Potential hazards of parenteral administration: 
  • Zinc overdose is possible, but unlikely if above dosing guidelines are followed
  • Symptoms of zinc overdose: nausea, vomiting, dehydration, electrolyte imbalances, dizziness, abdominal pain
  • Zinc sulfate contains 23% elemental zinc
  • Monitor serum zinc (normal: 10-20 micromol/L)
  • Gross excess of zinc can interfere with copper absorption and metabolism                     
  • Do not give undiluted due to phlebitis, tissue irritation and potential increased renal loss of minerals from a bolus injection

- Signs and symptoms of zinc deficiency include:                                                  

Growth suppression, anorexia, abnormal taste perception, skin lesions, diarrhea, alopecia

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