Parenteral Manual

Pantoprazole sodium

Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Gastric acid secretion inhibitor
Original Date: 
August 2005
Revised Date: 
April 2017
  • Treatment of conditions where a rapid reduction of gastric acid secretion is required such as reflux esophagitis in patients who cannot tolerate oral medications or in patients with severe GI bleeding.
Reconstitution and Stability: 
  • Reconstitute vial with 10 mL of 0.9% NaCl for a final concentraton of 4 mg/mL
  • Reconstituted solution stable 48 hrs at room temperature, 96 hrs refrigerated
  • Further diluted to 0.8 mg/mL in 0.9% NaCl stable 24 hours at room temp, 20 days refrigerated

- Solutions Compatible: D5W, 0.9% NaCl, ringer's lactate

-Y-site  Compatible: ampicillin, dimenhydrinate, dopamine, fentanyl, furosemide, gentamicin,  insulin regular,  methylprednisolone, metronidazole, morphine, nitroglycerin, piperacillin, potassium chloride, sodium bicarbonate, vasopressin

- Incompatible: ciprofloxacin, clindamycin, dobutamine, esmolol, hydromorphone, labetolol, midazolam, octreotide, potassium phosphate, zinc


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Direct

Usual dilution: 4 mg/mL

- 0.8 mg/mL for dose less than or equal to 4 mg
Infusion time: 2-5 minutes

IV Intermittent Infusion

Usual dilution: 4 mg/mL

- 0.8 mg/mL for dose less than or equal to 4 mg
Infusion time: over 15 minutes

IV Continuous Infusion

Usual dilution: 0.8 mg/mL




(For neonatal dosages, refer to Neonatal IV Drug Manual.)

  • Treatment is short-term: 7-10 days


  • 1-1.5 mg/kg/day IV once daily
  • Maximum: 40 mg/day

- GI Bleed:

  • 5-15 kg: 2 mg/kg/dose IV x 1 then 0.2 mg/kg/hr IV
  • >15-40 kg: 1.8 mg/kg/dose IV x 1 and then 0.18 mg/kg/hr IV
  • >40 kg: 80 mg/dose IV x 1 then 8 mg/hr IV
  • Maximum: 80 mg/dose
  • Maximum rate: 8 mg/hour


  • 40 mg IV once daily

- GI Bleed:

  • 80 mg/day IV loading dose followed by 8 mg/hr continuous IV infusion for 24-72 hours
  • Maximum: 240 mg/day has been administered
Potential hazards of parenteral administration: 
  • Diarrhea, headache, dizziness
  • Pruritis
  • Thrombophlebitis, abscess
  • Extensively metabolized hepatically
  • In patients with severe hepatic dysfunction, liver enzymes should be checked regularly and if an increase is noted, pantoprazole should be discontinued
  • When switching to oral, the same dose mg per mg should be ordered
  • Other additives - Edetate disodium (1 mg/ 40 mg vial)

The information contained on this website is provided for informational purposes only, as a guide to assist physicians, nurses and other healthcare providers in deciding on the appropriate care required for a particular patient. At all times, physicians, nurses and other healthcare providers must exercise their independent clinical judgment, based on their knowledge, training and experience, taking into account the specific facts and circumstances of each patient, when deciding on the appropriate course of investigation and/or treatment to recommend in a particular clinical situation.

CHEO has made every effort to ensure that the information contained on this website is as current and accurate as possible. However, changes can occur due to ongoing research and the constant influx of new information. Where possible, hospitals and healthcare practitioners should verify the information before acting on it.

Reliance on any information in this website is at the user's own risk. CHEO is not responsible or liable for any harm, loss or other consequences from the use or misuse of the information on this website.