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Tetramethylthionine chloride trihydrate
- Antidote for cyanide poisoning and drug induced methemoglobinemia.
- As a dye in diagnostic procedures.
Reconstitution and Stability:
- Available as 1% solution (10 mg/mL).
- Store at room temperature.
Solution Compatible: 0.9% NaCl
Incompatible: Do not dilute with other IV solutions
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
YES, by physician ONLY
Undiluted or diluted in NS
Inject over 5 minutes
|IV Intermittent Infusion
|IV Continuous Infusion
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
- Usual IV dose is 1-2 mg/kg injected over several minutes.
- Alternatively, an IV dose of 25-50 mg/m2 has been administered.
- Dose may be repeated in one hour if necessary.
Potential hazards of parenteral administration:
- Inject slowly to minimize formation of additional methemoglobinemia.
- May cause nausea, vomiting, abdominal and chest pain, dizziness, headache, profuse sweating, confusion and hypertension.
- With very high doses methemoglobinemia and hemolysis may occur.
- Monitoring: methemoglobin levels, blood pressure, serum bilirubin (unconjugated) and anemia.
- Use with caution in patients with glucose-6-phosphate dehydrogenase deficiency.
- Contraindicated in severe renal impairment.
- Do not inject subcutaneously or intrathecally as necrotic abscesses (subQ) and neural damage (I.T.) including paraplegia have occurred.
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