- Prevention and treatment of chemotherapy and radiation-related nausea and vomiting.
- Prevention and treatment of postoperative nausea and vomiting.
- Available as a 1 mg/mL vial
- Vials should be stored at room temperature
- Solution Compatible: D5W, 0.9%NS, dextrose-saline solutions
- Additive/Above Cassette Compatible: dexamethasone, methylprednisolone
- Y-site Compatible: acyclovir, amikacin, ampicillin, fluconazole, heparin, KCl (up to 40 mmol/L) metronidazole, morphine, TPN (amino acids/dextrose)
- Incompatible: amphotericin B
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
dilute in a small volume of D5W or NS over 5 minutes
|IV Intermittent Infusion||YES
Usual dilution: 0.2 mg/mL
Infusion time: 30-60 minutes
|IV Continuous Infusion||NO|
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
Chemotherapy and radiation-induced nausea and vomiting:
- Adults and Children (>2 years old):
- 10-40 mcg/kg/day divided once or twice daily (Maximum: 3 mg/dose or 9 mg/day)
- Administer initial dose 15-60 minutes before chemotherapy
Postoperative nausea and vomiting:
- Children (>4 years old):
- 20-40 mcg/kg given as a single dose (Maximum: 1 mg/dose)
- Administer before induction of surgery, immediately before reversal of anaesthesia, or postoperatively.
- 1 mg given as a single dose
- No dosage adjustment required in renal dysfunction.
- Headache, asthenia, somnolence
- Diarrhea, constipation, abdominal pain, decreased appetite
- Hypotension, hypertension, arrhythmias, A-V block
- Although doses of 100 mcg/kg have been used, 40 mcg/kg is the usual maximum dose
- Safety and efficacy have not been established for children <2 years of age.