- Treatment of infections caused by susceptible bacteria.
** Prescribing is restricted to Infectious Disease **
0.9% SODIUM CHLORIDE REQUIRED
- Shake to dissolve and let stand until clear.
- Reconstituted solutions stable 3 hours room temperature, 24 hours refrigerated.
- Solution ranges in color from colorless to pale yellow.
- Solutions Compatible: D5W, 0.9%NS, D5NS, ringer's solution, ringer's lactate
- Additives/Above Cassette Compatible: no information
- Y-site Compatible: aminophylline, dexamethasone, digoxin, diphenhydramine, fluconazole, furosemide, metoclopramide, morphine, norepinephrine, potassium (up to 40 mmol/L) vancomycin, TPN (amino acids/dextrose)
Incompatible: acyclovir, amphotericin B, diazepam, doxycycline, metronidazole, ondansetron, zidovudine.
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
|IV Intermittent Infusion||
|IV Continuous Infusion||NO|
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
Pediatric: (>3 months)
- Infection: 60 mg/kg/day IV ÷ Q 6 - 8 hours (Maximum: 3 g/day)
- Meningitis/Cystic Fibrosis patients with LRTI: 120 mg/kg/day IV ÷ Q 6 - 8 hours (Maximum: 6 g/day)
- Infection: 1.5-3 g/day IV ÷ Q 6 - 8 hours
- Meningitis: 6 g/day IV ÷ Q 8 hours
DOSING ADJUSTMENT IN RENAL IMPAIRMENT:
- CrCl 26-50 mL/minute: full dose Q 12 hours
- CrCl 10-25 mL/minute: ½ dose Q 12 hours
- CrCl <10 mL/minute: ½ dose Q 24 hours
- Meropenem is removed by hemodialysis; therefore, administer dose at completion of hemodialysis procedure
- Thrombophlebitis, phlebitis, inflammation at injection site
- Headache, diarrhea, pseudomembranous colitis, nausea, vomiting
- Transient increase in liver enzymes, liver function tests and bilirubin
- Elevated BUN and serum creatinine
- Rash, pruritus, urticaria
- Increases in platelets occur more frequently in pediatric patients
- Seizures (rare)
- Use with caution in patients with a history of seizures, CNS disease, CNS infection,
- May exhibit cross-allergy with penicillins or cephalosporins
- Monitor CBC with differential, serum creatinine and BUN, periodic hepatic function tests
- 1 gram of meropenem provides 90.2 mg (or 3.92 mmol) of sodium