Parenteral Manual

Omalizumab (NON-FORMULARY)

Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
IgE neutralizing antibody (Anti-IgE)
Original Date: 
March 2011
  • Treatment of moderate to severe persistent asthma in patients with a positive reaction to a perennial aeroallergen and who are inadequately controlled with inhaled steroids
Reconstitution and Stability: 
  • Refrigerate vials
  • Reconstitue 202.5 mg vial with 1.4 mL Sterile Water for Injection to get 150 mg in 1.2 mL (125 mg/mL)
  • Keeping vial upright swirl gently for 5 seconds every 5 minutes -DO NOT SHAKE
  • May take greater than 20 minutes to dissolve completely
  • Solution is clear or slightly opalescent
  • After reconstitution protect from light
  • Stable 8 hours refrigerated or 4 hours at room temperature- recommended to use within 4 hours following reconstitution



- NO COMPATIBILITY information available for other drugs


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)


YES - doses greater than 150 mg
           divided over more than 1 site
-slightly viscous - may take 5 - 10 seconds to inject

IV Direct NO
IV Intermittent Infusion NO
IV Continuous Infusion NO




(For neonatal dosages, refer to Neonatal IV Drug Manual.)

Pediatric (greater than 12 years / Adult:

  • 150 mg to 375 mg subcutaneous every 2 - 4 weeks
  • dosing based on the serum total IgE before therapy is started and body weight
Potential hazards of parenteral administration: 
  • Hypersensitivity reactions - urticaria, dermatitis, pruritus, throat and/or tongue edema
  • Dizziness, headache, fatigue, sinusitis
  • Injection site reactions
  • Viral infections, upper respiratory tract infection
  • Each vial contains 145 mg of sucrose (0.5 calories or 2.3 Joules)

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