Clomipramine (SPECIAL ACCESS PROGRAM)
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- Treatment of depressive disorders when there is an inability to tolerate oral administration
Reconstitution and Stability:
- Available as a 25 mg/2 mL injection
- Diluted solutions stable 24 hrs at room temperature or refrigerated
- Solutions Compatible: D5W, 0.9% NaCl
- Additives/Above Cassette Compatible: no information
- Y-site Compatible: no information
- Incompatible: hydrocortisone, sodium bicarbonate
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
|IV Intermittant Infusion
Usual dilution: 10 mg in 35-70 mL; larger doses in 125-500 mL
Infusion time: 1.5-3 hours
|IV Continuous Infusion
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
- Pediatric ORAL dose: 1-1.5 mg/kg/day PO ÷ Q8-12H.
Maximum: 3 mg/kg/day or 200 mg; whichever is smaller.
- Adolescent ORAL dose: 20-30 mg PO daily
- Intravenous dose conversion: 1/2 oral dose
- Pediatric IV dose not established
- Adolescents have received up to 200-300 mg IV once daily
- Initial Adult intravenous dose: 50-75 mg IV (once) daily
- Decrease dose in hepatic or renal failure
- Taper to discontinue to avoid withdrawal symptoms
Potential hazards of parenteral administration:
- Irritation at injection site
- Postural hypotension, sinus tachycardia, widening of QRS complex, bundle-branch block
- Drowsiness, confusion, agitation, dizziness, headache, tremors, convulsions, hallucinations
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