Parenteral Manual


Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
  • Treatment of depressive disorders when there is an inability to tolerate oral administration
Reconstitution and Stability: 
  • Available as a 25 mg/2 mL injection
  • Diluted solutions stable 24 hrs at room temperature or refrigerated                                     

- Solutions Compatible: D5W, 0.9% NaCl

- Additives/Above Cassette  Compatible: no information

- Y-site Compatible: no information

- Incompatible: hydrocortisone, sodium bicarbonate


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Push


IV Intermittant Infusion YES
Usual dilution: 10 mg in 35-70 mL; larger doses in 125-500 mL
Infusion time: 1.5-3 hours
IV Continuous Infusion NO

(For neonatal dosages, refer to Neonatal IV Drug Manual.)

  • Pediatric ORAL dose: 1-1.5 mg/kg/day  PO ÷ Q8-12H. 
    Maximum: 3 mg/kg/day or 200 mg; whichever is smaller.
  • Adolescent ORAL dose: 20-30 mg PO daily

         - Intravenous dose conversion:  1/2 oral dose                   

         - Pediatric IV dose not established                                                                     

  • Adolescents have received up to 200-300 mg IV once daily
  • Initial Adult intravenous dose: 50-75 mg IV (once) daily
  • Decrease dose in hepatic or renal failure
  • Taper to discontinue to avoid withdrawal symptoms
Potential hazards of parenteral administration: 
  • Irritation at injection site
  • Postural hypotension, sinus tachycardia, widening of QRS complex, bundle-branch block
  • Nausea                                             
  • Drowsiness, confusion, agitation, dizziness, headache, tremors, convulsions, hallucinations            

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