Parenteral Manual

Gonadorelin acetate

Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Luteinizing hormone releasing hormone, LUTREPULSE
Classification: 
Diagnostic agent
Original Date: 
August 2005
Indications: 
  • Diagnostic test for the evaluation of the pituitary component of the hypothalamus - pituitary - gonad axis           
Reconstitution and Stability: 
  • Use only the diluent provided
  • Stable for 45 days at room temperature
  • Stable for 30 days when refrigerated
  • Stable for 16 hours in catheter tubing
  • Does not contain preservative (follow CHEO puncture policy if vial dispensed)
Compatibility: 

- Solutions Compatible: D5W, NS

- Incompatible: DO NOT mix with other drugs

Administration: 

(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

SC YES
IM NO
IV Direct YES
Usual dilution: dilute in 3 mL of NS   
Infusion time: 30 seconds
IV Intermittent Infusion NO
IV Continuous Infusion NO
Dosage: 

(For neonatal dosages, refer to Neonatal IV Drug Manual.)

IV LHRH Stimulation Test:

  • BSA <1 m2 = 50 mcg
  • BSA >1 m2 = 100 mcg

SC LHRH Stimulation Test:

  • 100 mcg regardless of BSA
Potential hazards of parenteral administration: 
  • Rarely local swelling, thrombophlebitis, redness, pruritis at injection site      
  • Headache, lightheadedness and nausea
Notes: 
  • The test should be done in the absence of other drugs which directly affect the pituitary secretion of the gonadotropins (ex: androgens, estrogens, glucocorticoids, phenothiazines, dopamine antagonists)
  • Spironolactone may increase gonadotropin levels

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