Alternate Name(s):
BETAXIN®, Vitamin B1
Classification:
Vitamin B1
Original Date:
August 2005
Revised Date:
December 2019
Indications:
- Prophylaxis and treatment of thiamine deficiency
Reconstitution and Stability:
- Available as a 100 mg/mL injection
- Stable at room temperature
- Protect from light
- Stable in acidic solutions
- Addition to IV fluids for any great length of time is not recommended
Compatibility:
- Solutions Compatible: dextrose up to D10W, NS, dextrose-saline combinations, ringer's solution, ringer's lactate
- Additve/buretrol Compatible: no information
- Y-site Compatible: KCl, TPN (amino acids/dextrose)
- Incompatible: bisulfites, sulfites, copper ions, oxidizing and reducing agents, neutral solutions, alkaline solutions (e.g. sodium bicarbonate, barbiturates)
Administration:
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
| SC | NO |
| IM | YES, preferred route - Rapid and complete absorption |
| IV Direct | YES Usual dilution: 10 mg/mL Infusion time: 1-2 minutes |
| IV Intermittent Infusion | YES Usual dilution: 1 mg/mL Infusion time: at least 20 minutes |
| IV Continuous Infusion | YES, as a component of TPN |
Dosage:
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
Thiamine deficiency:
- Pediatric:
- 10-25 mg/dose IM/IV daily
- Adult:
- 5-30 mg/dose IM/IV 3 times a day
Recommended daily allowance (oral):
- <6 months: 0.2 mg
- 6-12 months: 0.3 mg
- 1-3 years: 0.5 mg
- 4-8 years: 0.6 mg
- 9-13 years: 0.9 mg
- 14-18 years:
- Male: 1.2 mg
- Female: 1 mg - >19 years:
- Male: 1.2 mg
- Female: 1.1 mg
Potential hazards of parenteral administration:
- Hypersensitivity reactions including anaphylaxis
- Feelings of warmth, weakness, sweating, nausea, restlessness
Notes:
- An intradermal test dose is recommended in patients with a history of food or drug allergy or suspected sensitivity to thiamine
- IV dextrose solutions increase thiamine requirements