Parenteral Manual

Hyoscine butylbromide (NON-FORMULARY)

Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Original Date: 
February 2016
  • To produce smooth muscle relaxation prior to radiological procedures where spasm may be a problem
  • Hyoscine butylbromide is a semisynthetic derivative of scopolamine but the doses are NOT equivalent (for hyoscine hydrobromide see SCOPOLAMINE monograph)
Reconstitution and Stability: 
  • Available as 20 mg/mL clear solution
  • Store at room temperature and protect from light
  • Stable 8 hours when mixed with D5W, D10W, 0.9% NaCl, ringer's solution, ringer's lactate

- Solutions Compatible:  D5W, D10W, ringer's solution, ringer's lactate


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Direct YES
Usual dilution: undiluted
Infusion time: over at least 1 minute

IV Intermittent Infusion

Usual dilution: dilute in at least 5 mL of IV fluid
Infusion time: 15 minutes
IV Continuous Infusion NO



(For neonatal dosages, refer to Neonatal IV Drug Manual.)


  • MR Enterography
    - less than or equal to 50 kg  - 0.3 mg/kg/dose IV
    - greater than 50 kg   - 20 mg/dose IV
Potential hazards of parenteral administration: 
  • Tachycardia or hypotension
  • Dry mouth, blurry vision, constipation, urinary retention
  • Disorientation, delirium, confusion, psychosis, drowsiness
  • Depressed respiration
  • Monitor heart rate
  • Infants and children are more susceptible than adults to the adverse effects of anticholinergics
  • Contraindicated in acute glaucoma, mechanical stenosis of the GI or urinary tract, tachycardia or cardiac arrhythmias
  • May enhance anticholinergic side effects of antihistamines
  • Use with caution in reflux esophagitis and cardiac disease
  • DO NOT confuse with hyoscine hydrobromide 

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