Parenteral Manual


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Antibiotic with beta-lactamase inhibitor
Original Date: 
July 2020
  • Empiric prophylaxis and treatment of animal and human bite wounds
  • Empiric treatment of chronic sinusitis requiring IV therapy
  • Treatment of prolonged appendicitis in patients who have received aminoglycosides > 8 days
Reconstitution and Stability: 
  • Reconstitute vial with 20 mL of sterile water for a final concentration of 50 mg amoxicillin/mL
  • Reconstituted vials stable for 15 minutes at room temperature
  • Diluted solutions stable for 1 hour at room temperature or 4 hours refrigerated

Available formulation: 1000 mg amoxicillin/200 mg clavulanic acid vial

  • Solutions: 0.9% NaCl, Lactated ringers
  • Additive: No information
  • Y-site compatible: Lorazepam, pantoprazole, propofol, vancomycin

(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV direct Yes for doses > 500 mg over 3-4 minutes
IV intermittent infusion

Yes for doses < 500 mg

Usual dilution:

  • < 500 mg: 10 mg/mL

Infusion time over 30 minutes

IV continuous infusion No



(For neonatal dosages, refer to Neonatal IV Drug Manual.)


  • Age < 3 months or weight < 4 kg: 25 mg amoxicillin/kg/dose every 12 hours
  • Age > 3 months: 25 mg/kg/dose every 8 hours  Maximum: 1000 mg amoxicillin/dose


  • 1000 mg amoxicillin IV every 8 hours

Renal Adjustments:

  • CrCl 10 - 30 mL/min: 25 mg amoxicillin/kg/dose (max 1000 mg) IV every 12 hours
  • CrCl < 10 mL/min: 25 mg amoxicillin/kg/dose (max 1000 mg) IV every 24 hours
  • Hemodialysis: 25 mg amoxicillin/kg/dose (max 1000 mg) IV every 24 hours plus 12.5 mg amoxicillin/kg/dose at the end of dialysis
Potential hazards of parenteral administration: 
  • Local reactions at injection site: pain, phlebitis, inflammation
  • Hypersensitivity reactions - manifested by rash, pruritis, bronchospasm, anaphylaxis
  • Diarrhea, nausea, and vomiting may occur
  • Sodium content: 2.7 mmol per 1000 mg of amoxicillin. 
  • Potassium content: 1 mmol per 1000 mg of amoxicillin

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