Parenteral Manual


Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Vitamin D Analog
Original Date: 
March 2006
  • Treatment and prevention of secondary hyperparathyroidism associated with chronic renal failure
Reconstitution and Stability: 
  • Available as a 5 microgram/mL solution for injection
  • Store at room temperature

- Compatibility Information: none known

- Incompatible: heparin (see notes)


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Direct


Infusion Time: 1 minute

Give via hemodialysis line at any time during dialysis

IV Intermittent Infusion No
IV Continuous Infusion No

(For neonatal dosages, refer to Neonatal IV Drug Manual.)


  • 0.04 - 0.08 mcg/kg/dose 3 times a week, depending on initial ionized PTH


  • Initial: 0.04 - 0.1 mcg/kg/dose up to 3 times per week (no more frequently than every 2 days)
  • Maximum dose: 0.24 mcg/kg/dose

- hold or decrease dose if corrected serum calcium level is elevated or if Calcium x Phosphorous is greater than 6.1

Potential hazards of parenteral administration: 
  • hypercalcemia
  • nausea, vomiting, diarrhea (occasional)
  • headache, chills, malaise, dizziness, lightheadedness (occasional)
  • allergic reactions (rare) (pruritus, rash, urticaria, facial and oral edema)
  • monitor serum calcium and phosphorous levels
  • may be given anytime during dialysis
  • Propylene glycol, an excipient in the solution can neutralize heparin

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