Parenteral Manual


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Alternate Name(s): 
Non-depolarizing skeletal neuromuscular blocking agent
Original Date: 
August 2005
Revised Date: 
December 2020
  • To ease endotracheal intubation
  • Adjunct to general anaesthesia and relaxes skeletal muscle during surgery or mechanical ventilation
Reconstitution and Stability: 
  • Available as 2 mg/mL in 10 mL multidose vial or 10 mg/mL in 20 mL single dose vial
  • Refrigerate and protect from light.  Stable 21 days at room temperature
  • Diluted solutions (0.1 - 0.4 mg/mL ,2 or 5mg/mL in D5W or NS) stable 24 hours at room temperature
  • Undiluted solutions stable 21 days at room temperature in original vial even if re-refrigerated
  • Solutions Compatible: D5W, 0.9% NaCl, D5NS
  • Additives/Above Cassette Compatible: no information
  • Y-site Compatible:  alfentanil, fentanyl, droperidol, midazolam, sufentanil,

Incompatible: alkaline solutions (e.g. barbiturate solutions), ketorolac, ringer's lactate, propofol


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Direct

Infusion time: 5-10 seconds

IV Intermittent Infusion YES
Usual dilution: 0.1-0.4 mg/mL
IV Continuous Infusion


Usual dilution: 0.1-0.4 mg/mL or 2mg/mL 


(For neonatal dosages, refer to Neonatal IV Drug Manual.)


  • 2-12 years: 0.1 mg/kg followed by maintenance dose of 0.03 mg/kg as needed to maintain neuromuscular blockade
  • > 12 years- Adult: 0.15-0.2 mg/kg followed by maintenance dose of 0.03 mg/kg 40-65 minutes later or as needed

Continuous Infusion:

  • Children >2 years: 1-4 mcg/kg/minute
  • Adult: 1-4 mcg/kg/minute  [up to 10 mcg/kg/minutes]
Potential hazards of parenteral administration: 
  • Hypersensitivity
  • Rash
  • Side effects of rash, bronchospasm, hypersensitivity
  • Many drug interactions- check with pharmacy
  • Monitor muscle twitch response to peripheral nerve stimulation, heart rate, blood pressure

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