Alternate Name(s):
VASOTEC® IV
Classification:
ACE Inhibitor, antihypertensive
Original Date:
August 2005
Revised Date:
December 2019
Indications:
- Management of mild to severe hypertension, CHF and asymptomatic left ventricular dysfunction when oral therapy is not feasible
Reconstitution and Stability:
- Available as a clear, colourless solution (1.25 mg/mL)
- Diluted solutions stable 24 hrs at room temperature
- DO NOT use if particulate matter or discoloration is observed
Compatibility:
- Solutions Compatible: D5W, NS, dextrose-saline combinations, dextrose 5% in ringer's lactate
- Additives/Above Cassette Compatible: no information
- Y-site Compatible: morphine, KCl, TPN (amino acids/dextrose)
- Incompatible: amphotericin B
Administration:
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
| SC | NO |
| IM | NO |
| IV Direct |
Not recommended. However an infusion over 60 seconds has been given without adverse effects |
| IV Intermittent Infusion | YES Usual dilution: 25 mcg/mL Infusion time: 5 minutes |
| IV Continuous Infusion | NO |
Dosage:
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
Pediatric:
- 5-10 mcg/kg/dose Q 8-24 hours
Adolescent/Adult:
- 0.625-1.25 mg/dose Q 6 hours
- Up to 5 mg Q 6 hours has been used for up to 36 hours
DOSAGE ADJUSTMENT IN RENAL IMPAIRMENT:
- CrCl 10-50 mL/minute: Administer 75-100% of dose
- CrCl <10 mL/minute: Administer 50% of dose
Potential hazards of parenteral administration:
- Hypotension, syncope
- Headache
- Angioedema
- Decreased renal function
- Hypoglycemia, hyperkalemia
Notes:
- Use with caution in renal impairment
- Severe hypotension may occur in patients who are sodium and/or volume depleted
- Monitor blood pressure, serum potassium, renal function, WBC