Parenteral Manual


Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
ACE Inhibitor, antihypertensive
Original Date: 
August 2005
Revised Date: 
December 2019
  • Management of mild to severe hypertension, CHF and asymptomatic left ventricular dysfunction when oral therapy is not feasible
Reconstitution and Stability: 
  • Available as a clear, colourless solution (1.25 mg/mL)
  • Diluted solutions stable 24 hrs at room temperature
  • DO NOT use if particulate matter or discoloration is observed    

- Solutions Compatible: D5W, NS, dextrose-saline combinations, dextrose 5% in ringer's lactate

- Additives/Above Cassette Compatible: no information

- Y-site Compatible: morphine, KCl, TPN (amino acids/dextrose)

- Incompatible: amphotericin B


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Direct

Not recommended.  However an infusion over 60 seconds has been given without adverse effects

IV Intermittent Infusion YES
Usual dilution:  25 mcg/mL
Infusion time: 5 minutes
IV Continuous Infusion NO

(For neonatal dosages, refer to Neonatal IV Drug Manual.)


  • 5-10 mcg/kg/dose Q 8-24 hours


  • 0.625-1.25 mg/dose Q 6 hours
  • Up to 5 mg Q 6 hours has been used for up to 36 hours


  • CrCl  10-50 mL/minute:  Administer 75-100% of dose
  • CrCl  <10 mL/minute:  Administer 50% of dose    
Potential hazards of parenteral administration: 
  • Hypotension, syncope                
  • Headache                                   
  • Angioedema                                                                                             
  • Decreased renal function
  • Hypoglycemia, hyperkalemia
  • Use with caution in renal impairment
  • Severe hypotension may occur in patients who are sodium and/or volume depleted
  • Monitor blood pressure, serum potassium, renal function, WBC


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