Parenteral Manual

Sodium benzoate

Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Ammonia detoxicant; Hyperammonemia agent; Urea cycle disorders treatment agent
Original Date: 
August 2005
Revised Date: 
September 2011
  • Treatment of hyperammonemia due to urea cycle enzyme deficiency in combination with arginine
Reconstitution and Stability: 
  •  Stable 24 hours at room temperature; discard unused portion of solution

- Solutions Compatible: D10W or D10W-0.2NS

- Additive/Above Cassette Compatible: arginine

- Y-site Compatible: no information

- Incompatible: no information


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Direct


IV Intermittent Infusion

YES  Central line preferred

Usual Dilution: 10 mg/mL

Infusion time: 90 minutes

IV Continuous Infusion YES  Central line preferred

Usual Dilution: 10 mg/mL


(For neonatal dosages, refer to Neonatal IV Drug Manual.)

  • Load: 250 mg/kg IV over 90 minutes
  • Maintenance: 250 mg/kg/day as continuous IV infusion 
  • 5.5 g/m2 IV bolus initially, followed by 5.5 g/m2/day as a continuous IV infusion
Potential hazards of parenteral administration: 
  • Metabolic acidosis, nausea and vomiting
  • Monitor serum ammonia level every 4 hours in the acute phase
  • Each mmol of sodium benzoate will bind 1 mmol ammonia

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