- Fluid and calorie replacement- 5% and 10% dextrose solutions
- Acute symptomatic episodes of hypoglycemia and insulin-induced hypoglycemia- 25% and 50% dextrose solutions
- Adjunct to insulin for the treatment of hyperkalemia- 25% and 50% dextrose solutions
- Store at room temperature not more than 25 °C, protect from freezing and extreme heat
- Do not use cloudy solutions
- Discard any unused portions
- Except for emergency situations, dilute concentrated dextrose solution for peripheral venous administration to a MAXIMUM concentration of 12.5%, solutions with a concentration greater than 12.5% should be administered via a central line.
- Please check the specific drug for interactions
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
Infusion rate: do not exceed 200 mg/kg/minute
|IV Intermittent Infusion||NO|
|IV Continuous Infusion||YES
Usual dilution: peripheral line- 12.5% dextrose. In emergency situations, 25% dextrose has been used peripherally
Infusion rate: 4.5-15 mg/kg/minute
Click here to access SDC Drug Infusion Sheet
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
- <6 mths: 0.25-0.5 g/kg/dose (1-2 mL/kg/dose of 25% solution).
Maximum: 25 g/dose
- >6 mths: 0.5-1 g/kg/dose (2-4 mL/kg/dose of 25% solution).
Maximum: 25 g/dose
- 0.5-1 g/kg (using 25% or 50% solution) combined with regular insulin 1 unit for every 4-5g of dextrose given; infuse over 2 hours (infusions as short as 30 minutes have been recommended).
- 25-50 g dextrose (250-500 mL D10W) with 10 units of regular insulin administered over 30-60 minutes, or alternatively, if urgent, 25 g dextrose (50 mL D50W) combined with 5-10 units of regular insulin infused over 5 minutes.
- 10-25 g dextrose solution (40-100 mL of 25% solution or 20-50 mL of 50% solution) I.V. slowly
- Pain, phlebitis at injection site due to rapid administration if a peripheral vein is used.
- Fluid and electrolyte disturbances: hyperglycemia, hypokalemia, hypophosphatemia, reactive hypoglycemia after infusion, glycosuria; side effects can be decreased by decreasing the rate of infusion.
- Mental confusion, unconsciousness, hyperosmolar syndrome
- Administer hypertonic solutions (>10%) via a central venous catheter.
- If extravasation occurs, click HERE for treatment guidelines.
- Contraindications: anuria; hypertonic solutions in patients with intercranial or intraspinal hemorrhage; hepatic coma; diabetic coma with hyperglycemia, or patients with delirium tremens and dehydration.
- Use with caution in premature infants and in patients with diabetes mellitus
- D5W is 50 mg of dextrose/mL
- D10W is 100 mg of dextrose/mL
- D25W is 250 mg of dextrose/mL
- D50W is 500 mg of dextrose/mL