Parenteral Manual


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Alternate Name(s): 
Original Date: 
August 2005
Revised Date: 
December 2019
  • Symptomatic relief of allergic symptoms caused by histamine release
  • Prevention and treatment of nausea, vomiting or vertigo associated with motion sickness
  • Prevention and treatment of drug-induced extrapyramidal reactions
Reconstitution and Stability: 
  • Available as a 50 mg/mL solution. Protect from light
  • Stable 91 days at room temperature or in fridge when diluted in 50 mL of 0.9% NaCl or D5W

- Solutions Compatible: dextrose up to D10W, 0.9% NaCl, dextrose-saline combinations, ringer's solution, ringer's lactate

- Additives/Above Cassette Compatible: morphine (for 15 minutes), dimenhydrinate, fentanyl, glycopyrrolate, hydromorphone, ranitidine

- Y-site Compatible: acyclovir, fluconazole, ondansetron, KCl (up to 40 mmol/L), TPN (amino acids/dextrose), meropenem

Incompatible: amphotericin B, dexamethasone, thiopentol


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)


NO  - except for Palliative Care Service

Usual dilution: 50 mg/mL
IV Direct

Usual dilution: 5 mg/mL
Infusion time: 5 minutes
Infusion rate: do not exceed 25 mg/minute

IV Intermittent Infusion YES
Usual dilution: 5 mg/mL
Infusion time: 10-15 minutes
Infusion rate: do not exceed 25 mg/minute
IV Continuous Infusion YES
Usual dilution: 5 mg/mL

(For neonatal dosages, refer to Neonatal IV Drug Manual.)


  • 5 mg/kg/day IM/IV ÷ Q 6-8 hours PRN
  • Usual dose 1 mg/kg per dose
  • Maximum: 50 mg/dose


  • 25-50 mg/dose IM/IV Q 4 hours PRN
Potential hazards of parenteral administration: 
  • Irritation at IM injection site - rotate site
  • Avoid SC or perivascular injection due to irritation effects
  • Anaphylaxis (rarely)
  • CNS depression, drowsiness/sedation, dryness of mouth                                               
  • Paradoxical CNS stimulation may occur in children                                      
  • Hypotension, palpitations, tachycardia
  • Chest tightness, thickened bronchial secretions, wheezing
  • Changes in blood pressure and ECG
  • Caution in patients with asthma, chronic obstructive pulmonary disease, cardiac disease, hypertension, narrow angle glaucoma
  • Potentiates side effects of anticholinergics and CNS depressants                        
  • Dosage adjustment may be necessary in severe renal impairment                      
  • Should not be used in acute asthma attacks

The information contained on this website is provided for informational purposes only, as a guide to assist physicians, nurses and other healthcare providers in deciding on the appropriate care required for a particular patient. At all times, physicians, nurses and other healthcare providers must exercise their independent clinical judgment, based on their knowledge, training and experience, taking into account the specific facts and circumstances of each patient, when deciding on the appropriate course of investigation and/or treatment to recommend in a particular clinical situation.

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