- Treatment of primary systemic carnitine deficiency.
- Acute and chronic treatments of patients with an inborn error of metabolism, which results in a secondary carnitine deficiency.
- Prevention and treatment of carnitine deficiency in hemodialysis patients.
- TPN supplementation in neonates/infants with little or no enteral intake.
- Prophylaxis and treatment of valproate-associated hepatotoxicity.
- Available as 200 mg/mL vials. Store at room temperature
- Stable in TPN for up to 24 hours in PVC plastic bags at room temperature
- Solution Compatible: NS, lactated ringer's up to a concentration of 8 mg/mL
- Additive/Above Cassette Compatible: TPN (amino acids/dextrose)
- Y-site Compatible: TPN (amino acids/dextrose)
- Incompatible: no information
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
Usual dilution: 200 mg/mL
Infusion time: 2-3 minutes
|IV Intermittent Infusion||
|IV Continuous Infusion||YES: may be added to TPN and infused as per TPN rate|
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
- Carnitine deficiency (metabolic aciduria):
- 50 mg/kg bolus followed by:
- 50 mg/kg/day as a continuous infusion OR
- 50 mg/kg/day divided Q4-6H. Increase as needed to 300 mg/kg/day
- Hemodialysis: 5-20 mg/kg/dose following dialysis
- TPN supplementation: 10-20 mg/kg/day
- Valproate-associated hepatotoxicity:
- Treatment: 150-500 mg/kg/day (Maximum: 3 g/day)
- Prophylaxis: 15-100 mg/kg/day (Maximum: 100 mg/kg/day)
- Carnitine deficiency:
- Initial dose: 50 mg/kg given IV push or by infusion followed by a daily dose
- Daily dose: 50 mg/kg given in divided doses Q 3-4 hours
- Maximum dose: 300 mg/kg
- Hemodialysis patients :
- 5-20 mg/kg after each dialysis session
- Transient nausea and vomiting, gastritis, body odor
- Plasma carnitine concentration should be obtained prior to beginning therapy; weekly and monthly monitoring of blood chemistries, vital signs and plasma carnitine concentrations is recommended