Parenteral Manual


Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
TTB skin test, MANTOUX, PPD
TB skin test
Original Date: 
August 2005
Revised Date: 
  • An aid in the detection of infection with Mycobacterium tuberculosis
Reconstitution and Stability: 
  • Available as 5 test units/0.1 mL dose
  • Vial stable 1 month refrigerated once punctured. Protect from light

- DO NOT mix with any other drug or IV fluid


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

Intracutaneous YES
Intradermal YES
  • Avoid subcutaneous injection

(For neonatal dosages, refer to Neonatal IV Drug Manual.)

  • 5 test units (0.1 mL) intracutaneously
Potential hazards of parenteral administration: 
  • Vesiculation, ulceration or necrosis at test site in sensitive patients
  • Pain, pruritus and discomfort
  • Erythematous reactions at injection site
  • Hypersensitivity reactions
  • The test should be read 48-72 hours after administration; sensitivity is indicated by induration, usually accompanied by erythema
  • Widest diameter of distinctly palpable induration is recorded in millimetres (mm)

Positive reaction:

 >10 mm

Doubtful reaction: 

5-9 mm; if known contacts considered positive reaction

Negative reaction: 

< 5 mm


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