- Treatment of hypotension and vascular failure in shock
- Maintenance of blood pressure during anesthesia
- Treatment of supraventricular tachycardia
- Stable at room temperature
- DO NOT use darkened solutions or solutions containing a precipitate
- Stable for 48 hours diluted in D5W and for 24 hours diluted in NS when kept at room temperature
Phenylephrine 100 mcg/mL:
-
Draw up 5 mg (0.5 mL) of phenylephrine 10 mg/mL and add to 49.5 mL of NS
- Solutions Compatible: dextrose up to D10W, 0.9% NaCl, ringer's solution, ringer's lactate
- Additive/Above Cassette Compatible: caffeine
- Y-site Compatible: atropine, cefotaxime, cefuroxime, dexamethasone, dobutamine, dopamine, fentanyl, furosemide, lidocaine, midazolam, morphine, KCl, ranitidine
- Incompatible: alkalis, amphotericin B, ferric salts and other metals, phenytoin, thiopental
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
| SC | YES |
| IM | YES |
| IV Direct |
YES, BP monitoring |
| IV Intermittent Infusion | NO |
| IV Continuous Infusion |
YES, continuous BP monitoring (use standard concentration of 100 mcg/mL on syringe pump) Infusion rate: rate as per dosage section |
Click here to access SDC Drug Infusion Sheet
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
Pediatric:
- Hypotension/shock:
- 0.1 mg/kg/dose IM/SC Q 1-2 hours PRN (Maximum: 5 mg)
- 5-20 microgram/kg/dose IV Push Q 10-15 minutes PRN
- 0.1-0.5 microgram/kg/minuteIV Infusion, titrate as required
- Paroxysmal supraventricular tachycardia:
- 5-10 microgram/kg IV over 20-30 seconds, increase by 10 microgram/kg increments up to 100 microgram/kg/total dose
- Tetralogy spells:
- 5 microgram/kg/dose IV, followed by infusion of 0.1-4 microgram/kg/minute
Adult:
- Hypotension/shock:
- 2-5 mg/dose IM/SC Q 1-2 hours PRN (Maximum: 5 mg)
- 0.1-0.5 mg/dose IV Push Q 10-15 minutes PRN
- 100-180 microgram/minuteIV Infusion, titrate as required; maintenance rate of 40-60 mcg/minute
- Paroxysmal supraventricular tachycardia:
- 0.25-0.5 mg IV over 20-30 seconds
- Ventricular extrasystoles, ventricular tachycardia, hypertension, severe reflex bradycardia, headache
- Tingling in extremities or feeling of coolness in the skin
- Extravasation may produce local vasoconstriction, necrosis and sloughing of the skin (may be treated with local infiltration of phentolamine)
- Administer into a large vein to prevent the possibility of extravasation
- Monitor HR, BP, CVP and arterial blood gases
- Use with caution in patients with hyperthyroidism, bradycardia, partial heart block, myocardial disease
- Use with tricyclic antidepressants, MAO inhibitors or oxytocic drugs may produce severe hypotensive
DILUTED PHENYLEPHRINE 100 mcg/mL
FOR MINI BOLUS DOSING
- Diluted phenylephrine be requested by physicians during resus cases.
- It is sometimes referred to as a "Phenyl Spritzer".).
- The physician will use the 10 ml diluted phenylephrine syringe to administer small mini boluses (eg 1 - 2mL).
A 10 mL syringe of diluted phenylephrine is made by adding 0.1 mL of phenylephrine 10 mg/mL to 9.9mL of 0.9% NaCl.
| Phenylephrine 10mg/mL | 0.1 mL |
| 0.9% NaCl | 9.9 mL |