Parenteral Manual

Scopolamine hydrobromide

Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
HYOSCINE HYDROBROMIDE
Classification: 
Anticholinergic agent
Original Date: 
August 2005
Revised Date: 
September 2011
Indications: 
  • Preoperative medication to produce amnesia and decrease salivation and respiratory secretions
  • DO NOT confuse with hyoscine butylbromide (Buscopan®)                   
Reconstitution and Stability: 
  • Available as 0.6 mg/mL ampoules
  • Store at room temperature                                       
  • Protect from light
Compatibility: 

- Solutions Compatible: SWI, D5W, NS, ringer's solution, ringer's lactate

- Additive/Above Cassette Compatible: atropine, chlorpromazine HCl, dimenhydrinate, diphenhydramine, droperidol, fentanyl, glycopyrrolate, hydromorphone, hydroxyzine, meperidine HCl, metoclopramide, morphine sulphate, pentobarbital sodium, prochlorperazine, promethazine HCl, thiopental; use within 15 minutes of mixing

- Y-site Compatible: heparin, propofol, KCl (up to 40 mmol/L)

- Incompatible: no information

Administration: 

(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

SC YES
IM YES
IV Direct

YES
Usual dilution: dilute with an equal volume of Sterile Warter for Injection
Infusion time: over 2-3 minutes
IV Intermittent Infusion NO
IV Continuous Infusion NO
Dosage: 

(For neonatal dosages, refer to Neonatal IV Drug Manual.)

Pediatric:     

  • 0.006 mg/kg/dose SC/IM/IV preop;  may repeat Q 6-8 hours if needed
  • Maximum dose: 0.3 mg/dose

Adult:

  • 0.3-0.65 mg SC/IM/IV pre-operative; may repeat 3-4 times/day
Potential hazards of parenteral administration: 
  • Tachycardia, palpitations                                                             
  • Disorientation, delirium, confusion, hyperactivity - especially in children                                        
  • Urinary retention, constipation, dry mouth
  • Increased ocular pressure, dilation of pupils, blurred vision
  • Nausea, vomiting
Notes: 
  • Avoid use in patients with glaucoma, urinary or GI obstruction
  • Use with caution with hepatic or renal dysfunction, cardiac disease, seizures or psychoses
  • Antihistamines, phenothiazines and tricyclic antidepressants will enhance the drug's effects
  • Well absorbed orally;  injectable form may be given orally
  • Preoperative doses should be given 30-60 minutes prior to induction of anesthesia
  • DO NOT confuse with hyoscine butylbromide (Buscopan®)
References: 

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