Parenteral Manual


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Alternate Name(s): 
6% Hydroxyethyl starch 130/0.4 in an isotonic electrolyte injection
Plasma volume expander
Original Date: 
July 2012
Revised Date: 
  • Plasma volume expander for the treatment of hypovolemia
Reconstitution and Stability: 
  • Available in 250 mL infusion bags
  • Use immediately after bag is opened
  • Clear to slightly opalescent soluton,  colourless to slightly yellow
  • Stable at room temperature, avoid freezing
  • Discard solution if showing haziness, particulate matter, precipitate, discoloration, or leakage
  • Do not vent
  • Discard unused portion

- Solutions Compatible:  no information

- Incompatible:  Mixing with other drugs should be avoided.  If, in exceptional cases, a mixture with other drugs is required, care should be taken with the compatibility (clouding or precipitation)


(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

IV Push NO
IV Intermittent Infusion YES - Infusion rate dependent on clinical situation & individual patient
IV Continuous Infusion YES




(For neonatal dosages, refer to Neonatal IV Drug Manual.)

- Daily dose and rate of infusion depend on the individual patient's colloid needs, taking into account disease state as well as the hemodynamic and hydration status

- Infuse initial 10 - 20 mL slowly, due to possible anaphylactoid reactions


  • < 2 years old:  average dose:  16 mL/kg


  • Average dose:  33 mL/kg/day
  • Maximum:  50 mL/kg/day
Potential hazards of parenteral administration: 
  • Pruritis, anaphylactoid reactions
  • Large volumes will alter coagulation mechanisms and decrease hematocrit and plasma proteins
  • Elevated serum amylase
  • Caution using in patients with severe liver disease or severe bleeding disorders
  • Contraindicated in patients with:
    - intracranial bleeding
    - known hypersensitivity to hydroxyethylstarch
    - severe hypernatremia or severe hyperchloremia
    - dialysis or renal failure with oliguria or anuria not related to hypovolemia
    - fluid overload, especially pulmonary edema and congestive heart failure
  • Monitor serum electrolytes
  • Has a volume effect of approximately 100% (of infused volume) which lasts approximately 4 - 6 hours
  • pH:  5.7 - 6.5
  • Osmolarity:   286.5 mosmol/L
  • Approximate concentraion of electrolyes per litre:  Sodium 137 mmol, Potassium 4 mmol, Magnesium 1.5 mmol, Chloride 110 mmol, and Acetate 34 mmol





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