Parenteral Manual

Fosaprepitant (STUDY DRUG)

Disclaimer: Official controlled document is the CHEO online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
EMEND
Classification: 
AHFS 56:22.92 Miscellaneous Antiemetics
Original Date: 
September 2013
Indications: 
  • Prevention of acute and delayed nausea and vomiting due to highly emetogenic cancer chemotherapy
Reconstitution and Stability: 

 

  

VIAL SIZE 0.9% SODIUM CHLORIDE for INJECTION FINAL CONCENTRATION
150 mg   5 mL    30 mg/mL 
  •  Add saline towards vial wall to prevent foaming
  • Swirl gently to dissolve.  DO NOT SHAKE
  • Further dilute with 0.9% NaCl to prepare a 1 mg/mL solution
Compatibility: 

-  Solutions Compatible:  0.9% NaCl

Incompatible:  solutions containing divalent cations (i.e.  Ca+2, Mg+2) including Lactated Ringer's solution

Administration: 

(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)

SC NO
IM NO
IV Push NO
IV Intermittent Infusion YES
Usual dilution:  1 mg/mL
Infusion time:  1 hour
IV Continuous Infusion NO
Dosage: 

(For neonatal dosages, refer to Neonatal IV Drug Manual.)

Pediatric:

-  as per protocol:  3 mg/kg

Adult:

-  150 mg

Potential hazards of parenteral administration: 
  • Hypersensitivity reactions including flushing, erythema, and dyspnea have occurred during infusion of fosaprepitant.  Discontinue infusion and administer appropriate therapy
  • Irritation at the injection site
Notes: 
  • Fosaprepitant is an inhibitor of CYP3A4 enzyme so there is a potential for many drug interactions
  • Fosaprepitant cannot be removed by hemodialysis
  • Reported side effects:  asthenia, fatigue, constipation, diarrhea, nausea, decreased appetite, headache, dizziness and hiccups

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