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Luteinizing hormone releasing hormone, LUTREPULSE
- Diagnostic test for the evaluation of the pituitary component of the hypothalamus - pituitary - gonad axis
Reconstitution and Stability:
- Use only the diluent provided
- Stable for 45 days at room temperature
- Stable for 30 days when refrigerated
- Stable for 16 hours in catheter tubing
- Does not contain preservative (follow CHEO puncture policy if vial dispensed)
- Solutions Compatible: D5W, NS
- Incompatible: DO NOT mix with other drugs
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
Usual dilution: dilute in 3 mL of NS
Infusion time: 30 seconds
|IV Intermittent Infusion
|IV Continuous Infusion
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
IV LHRH Stimulation Test:
- BSA <1 m2 = 50 mcg
- BSA >1 m2 = 100 mcg
SC LHRH Stimulation Test:
- 100 mcg regardless of BSA
Potential hazards of parenteral administration:
- Rarely local swelling, thrombophlebitis, redness, pruritis at injection site
- Headache, lightheadedness and nausea
- The test should be done in the absence of other drugs which directly affect the pituitary secretion of the gonadotropins (ex: androgens, estrogens, glucocorticoids, phenothiazines, dopamine antagonists)
- Spironolactone may increase gonadotropin levels
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