Alternate Name(s):
Zemplar
Classification:
Vitamin D Analog
Original Date:
March 2006
Indications:
- Treatment and prevention of secondary hyperparathyroidism associated with chronic renal failure
Reconstitution and Stability:
- Available as a 5 microgram/mL solution for injection
- Store at room temperature
Compatibility:
- Compatibility Information: none known
- Incompatible: heparin (see notes)
Administration:
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
| SC | No |
| IM | No |
| IV Direct |
Yes Infusion Time: 1 minute Give via hemodialysis line at any time during dialysis |
| IV Intermittent Infusion | No |
| IV Continuous Infusion | No |
Dosage:
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
Pediatric:
- 0.04 - 0.08 mcg/kg/dose 3 times a week, depending on initial ionized PTH
Adult:
- Initial: 0.04 - 0.1 mcg/kg/dose up to 3 times per week (no more frequently than every 2 days)
- Maximum dose: 0.24 mcg/kg/dose
- hold or decrease dose if corrected serum calcium level is elevated or if Calcium x Phosphorous is greater than 6.1
Potential hazards of parenteral administration:
- hypercalcemia
- nausea, vomiting, diarrhea (occasional)
- headache, chills, malaise, dizziness, lightheadedness (occasional)
- allergic reactions (rare) (pruritus, rash, urticaria, facial and oral edema)
Notes:
- monitor serum calcium and phosphorous levels
- may be given anytime during dialysis
- Propylene glycol, an excipient in the solution can neutralize heparin