Alternate Name(s):
Classification:
Ammonia detoxicant; Hyperammonemia agent; Urea cycle disorders treatment agent
Original Date:
August 2005
Revised Date:
September 2011
Indications:
- Treatment of hyperammonemia due to urea cycle enzyme deficiency in combination with arginine
Reconstitution and Stability:
- Stable 24 hours at room temperature; discard unused portion of solution
Compatibility:
- Solutions Compatible: D10W or D10W-0.2NS
- Additive/Above Cassette Compatible: arginine
- Y-site Compatible: no information
- Incompatible: no information
Administration:
(For approved routes of administration by nursing personnel, refer to Policy for the Administration of Intravenous Medications.)
| SC | NO |
| IM | NO |
| IV Direct |
NO |
| IV Intermittent Infusion |
YES Central line preferred Usual Dilution: 10 mg/mL Infusion time: 90 minutes |
| IV Continuous Infusion | YES Central line preferred
Usual Dilution: 10 mg/mL |
Dosage:
(For neonatal dosages, refer to Neonatal IV Drug Manual.)
- Load: 250 mg/kg IV over 90 minutes
- Maintenance: 250 mg/kg/day as continuous IV infusion
OR - 5.5 g/m2 IV bolus initially, followed by 5.5 g/m2/day as a continuous IV infusion
Potential hazards of parenteral administration:
- Metabolic acidosis, nausea and vomiting
Notes:
- Monitor serum ammonia level every 4 hours in the acute phase
- Each mmol of sodium benzoate will bind 1 mmol ammonia
References: