Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Original Date: 
December 2008
Revised Date: 
November 2019
  • Treatment of hypertension
  • PO
  • 0.1 - 0.2 mg/kg/day daily or divided Q12H
  • Maximum daily dose: 0.6 mg/kg/day

Reduce initial dose in patients with hepatic impairment. Refer to available references or clinical pharmacist for dosage adjustment

Side Effects: 
  • CVS: hypotension, tachycardia, edema
  • Dermatologic: rash
  • Hepatic: jaundice, liver enzymes elevated
Parameters to Monitor: 
  • BP, HR
  • Liver enzymes
Reconstitution and Stability: 





- Mistry K, Gupta C. Neonatal Hypertension. NeoReviews. June 2017;18 (6): e357-e371

- Buck ML. Amlodipine Use in Pediatric Hypertension. Pediatr Pharm 9(7), 2003. Available from:



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