Alternate Name(s):
Lasix
Classification:
Diuretic
Original Date:
March 1993
Revised Date:
August 2022
Indications:
- Pulmonary edema/congestive heart failure
- As adjunctive therapy for BPD
Administration:
- IV direct: over 5 minutes (maximum: 1 mg/kg/dose)
- IV intermittent infusion: over 15 - 30 minutes
- IV continuous infusion
- PO
Dosage:
- IV:
- IV direct / IV intermittent infusion:
- 1 - 2 mg/kg/dose Q12 - 24H
- ** Follow above administration directives for IV administration**
- IV continuous infusion: (rarely used)
- 0.05 mg/kg/hr ; titrate dose to clinical effect
- IV direct / IV intermittent infusion:
- PO:
- 1 - 2 mg/kg/dose Q12 - 24H
Side Effects:
- CVS: hypotension, cardiac arrhythmias (rare)
- Endocrine and metabolic: hyperglycemia, hypocalcemia, hypokalemia, hyponatremia, hypomagnesemia, metabolic alkalosis
- Otic: potentially ototoxic, especially with concomitant aminoglycosides
- Renal: hypercalciuria, interstitial nephritis, nephrocalcinosis
Parameters to Monitor:
- Serum electrolytes, serum creatinine
- Weight, urine output
- BP
- HR
Reconstitution and Stability:
CHEO:
IV direct/ IV intermittent infusion/ IV continuous infusion
- Furosemide 10 mg/mL
- Take 1 mL (10 mg) and add to 9 mL of 0.9% NaCl
- Final concentration: 1 mg/mL
TOH:
IV direct/ IV intermittent infusion
- Furosemide 10 mg/mL
- Take 1 mL (10 mg) and add to 9 mL of 0.9% NaCl
- Final concentration: 1 mg/mL
Continuous infusion
- Furosemide 10 mg/mL
- Take 1 mL (10 mg) and add to 19 mL of D5W
- Final concentration: 0.5 mg/mL
Compatibility:
- Solutions Compatible: D5W, D10W, 0.9 % NaCl, dextrose-saline combinations
- Y-site Compatible: calcium gluconate, epinephrine, fentanyl, heparin, KCl up to 40 mmol/L, morphine, SMOF, TPN
Incompatible: dobutamine, dopamine, fluconazole, gentamicin, midazolam, vancomycin
Notes:
- Do not use if IV solution is yellow
References:
-American Society of Health-System Pharmacists. Handbook on Injectable Drugs. 19th Edition. Bethesda: American Society of Health-System Pharmacists; 2017