||Neonatal Drug Therapy Manual
Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.
PO: administer 15 - 30 minutes before feeds
Separate administration from antacids, or ranitidine by 2 hours
1.2 - 2.4 mg/kg/day divided TID or QID
Dose adjustment required in renal impairment. Refer to available references or clinical pharmacist for dosage adjustment
- NOTE: Assess risk-benefit due to the possible risk of domperidone-induced QTc prolongation
Parameters to Monitor:
- Serum electrolytes and baseline QT interval measurement prior to initiation of domperidone and repeated once on domperidone therapy
Reconstitution and Stability:
- Do not administer if patient is taking ketoconazole, fluconazole, phenobarbital, phenytoin, erythromycin or an other drug that will affect the metabolism of domperidone by the cytochrome CYP3A4
The information contained on this website is provided for informational purposes only, as a guide to assist physicians, nurses and other healthcare providers in deciding on the appropriate care required for a particular patient. At all times, physicians, nurses and other healthcare providers must exercise their independent clinical judgment, based on their knowledge, training and experience, taking into account the specific facts and circumstances of each patient, when deciding on the appropriate course of investigation and/or treatment to recommend in a particular clinical situation.
CHEO has made every effort to ensure that the information contained on this website is as current and accurate as possible. However, changes can occur due to ongoing research and the constant influx of new information. Where possible, hospitals and healthcare practitioners should verify the information before acting on it.
Reliance on any information in this website is at the user's own risk. CHEO is not responsible or liable for any harm, loss or other consequences from the use or misuse of the information on this website.