Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Prokinetic agent
Original Date: 
December 2008
Revised Date: 
June 2010
  • Gastroesophageal reflux
  • PO: administer 15 - 30 minutes before feeds
    • Separate administration from antacids, or ranitidine by 2 hours
  • 1.2 - 2.4 mg/kg/day divided TID or QID
  • Dose adjustment required in renal impairment. Refer to available references or clinical pharmacist for dosage adjustment
  • NOTE: Assess risk-benefit due to the possible risk of domperidone-induced QTc prolongation
Side Effects: 
  • CVS: edema, palpitations, QT interval prolongation
  • Dermatologic: rash, urticaria
  • Endocrine and metabolic: breast enlargement, galactorrhea, possible hypernatremia

  • GI: diarrhea, constipation
Parameters to Monitor: 
  • Serum electrolytes and baseline QT interval measurement prior to initiation of domperidone and repeated once on domperidone therapy
Reconstitution and Stability: 




  • Do not administer if patient is taking ketoconazole, fluconazole, phenobarbital, phenytoin, erythromycin or an other drug that will affect the metabolism of domperidone by the cytochrome CYP3A4

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