Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
HCTZ, Microzide, Hydrodiuril
Thiazide Diuretic; antihypertensive
Original Date: 
March 2022
Revised Date: 
March 2022
  • Edema, hypertension
  • Adjunct medication when using diazoxide
  • PO
  • Usual dose: 2 - 4 mg/kg/day divided in 2 doses

  • To manage fluid retention due to diazoxide: start at 1 mg/kg/day divided daily or bid    

Side Effects: 
  • Endocrine and metabolic: electrolyte abnormalities (ex: hypokalemia, hypomagnesemia, hyponatremia), hyperglycemia

  • Hypotension

Parameters to Monitor: 
  • Serum electrolytes
  • Blood glucose
  • Signs of edema
  • BP
  • Urine output


  • Lexi-Comp Database, accessed March 2022
  • Preneet Cheema Brar, Ryan Heksch, Kristina Cossen, Diva D De Leon, Manmohan K Kamboj, Seth D Marks, Bess A Marshall, Ryan Miller, Laura Page, Takara Stanley, Deborah Mitchell, Paul Thornton, Management and Appropriate Use of Diazoxide in Infants and Children with Hyperinsulinism, The Journal of Clinical Endocrinology & Metabolism, Volume 105, Issue 12, December 2020, Pages 3750–3761.

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