Neonatal Drug Therapy Manual

Pyridoxine (Vitamin B6)

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Original Date: 
August 1997
Revised Date: 
September 2015
  • Treatment of pyridoxine-dependent seizures
  • Prevention of drug-induced vitamin B6 deficiency (eg. Isoniazid)
  • IV direct / IV intermittent infusion: do not exceed 50 mg/minute
  • PO

Pyridoxine-dependent seizures

  • Initial: IV/PO (IV preferred) 50 -100 mg
  • Maintenance: IV/PO (oral preferred) 50 - 100 mg/day


Prevention of drug-induced vitamin B6 deficiency

  • PO: 1 - 2 mg/kg/day once a day


Side Effects: 
  • Rarely
Parameters to Monitor: 
  • When given for Pyridoxine-dependent seizures, monitor EEG concurrently

- Solutions Compatible: D5W, 0.9% NaCl


- Gospe SM. Neonatal Vitamin-responsive Epileptic Encephalopathies. Chang Gung Med J 2010;33:1-12

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