Neonatal Drug Therapy Manual

Pyridoxine (Vitamin B6)

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Updated January 26, 2022 - 6:00pm

Classification: 
Vitamin
Original Date: 
August 1997
Revised Date: 
September 2015
Indications: 
  • Treatment of pyridoxine-dependent seizures
  • Prevention of drug-induced vitamin B6 deficiency (eg. Isoniazid)
Administration: 
  • IV direct / IV intermittent infusion: do not exceed 50 mg/minute
  • PO
Dosage: 

Pyridoxine-dependent seizures

  • Initial: IV/PO (IV preferred) 50 -100 mg
  • Maintenance: IV/PO (oral preferred) 50 - 100 mg/day

 

Prevention of drug-induced vitamin B6 deficiency

  • PO: 1 - 2 mg/kg/day once a day

 

Side Effects: 
  • Rarely
Parameters to Monitor: 
  • When given for Pyridoxine-dependent seizures, monitor EEG concurrently
Compatibility: 

- Solutions Compatible: D5W, 0.9% NaCl

References: 

- Gospe SM. Neonatal Vitamin-responsive Epileptic Encephalopathies. Chang Gung Med J 2010;33:1-12

The information contained on this website is provided for informational purposes only, as a guide to assist physicians, nurses and other healthcare providers in deciding on the appropriate care required for a particular patient. At all times, physicians, nurses and other healthcare providers must exercise their independent clinical judgment, based on their knowledge, training and experience, taking into account the specific facts and circumstances of each patient, when deciding on the appropriate course of investigation and/or treatment to recommend in a particular clinical situation.

CHEO has made every effort to ensure that the information contained on this website is as current and accurate as possible. However, changes can occur due to ongoing research and the constant influx of new information. Where possible, hospitals and healthcare practitioners should verify the information before acting on it.

Reliance on any information in this website is at the user's own risk. CHEO is not responsible or liable for any harm, loss or other consequences from the use or misuse of the information on this website.