Alternate Name(s):
Dobutrex
Classification:
Sympathomimetic
Original Date:
March 1993
Revised Date:
June 2024
Indications:
- Blood pressure support
- Treatment of cardiac decompensation in Persistent Pulmonary Hypertension of the Newborn
Administration:
- IV continuous infusion
Dosage:
- Usual dosing range: 2.5- 10 mcg/kg/minute; maximum 20 mcg/kg/minute
- Titration Recommendation: titrate by 2.5- 5 mcg/kg/minute, Q 15 minutes1
1 meant to be general guidance for titrations, use clinical judgment
Side Effects:
- CVS: tachycardia, arrhythmias, hypertension
- Local: tissue sloughing/necrosis with extravasation-consider treating with phentolamine 0.5 mg/mL solution
Parameters to Monitor:
- HR
- BP
- ECG
- Urine output
- Injection site
Reconstitution and Stability:
- DOBUTamine 12.5 mg/mL:
- Take 1.28 mL (16 mg) and add to 18.72 mL D5W
- Final concentration: 800 mcg/mL
- DOBUTamine 12.5 mg/mL:
- Take 2.56 mL (32 mg) and add to 17.44 mL D5W
- Final concentration: 1600 mcg/mL
Compatibility:
- Solutions Compatible: dextrose up to D10W, 0.9% NaCl, dextrose-saline combinations
- Y-site Compatible: dopamine, epinephrine, fentanyl, heparin(< 0.5 units/mL), KCl, morphine, SMOF, TPN
- Incompatible: acyclovir, alteplase, furosemide, insulin, midazolam, sodium bicarbonate
Notes:
- Pink discolouration indicates oxidation, but no potency loss over 24 hours
References:
- Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 19th edition. Hudson: Lexi-Comp Inc.; 2012
- Trissel LA. Handbook on Injectable Drugs. 16th Edition. Bethesda: American Society of Health-System Pharmacists 2011
- Evidence-based Practice for Improving Quality (EPIQ) Recommendations on Hemodynamics, 2023
- NeoFax® and Lexi-Comp® compatibility, accessed April 2024.