Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Narcotic Antagonist
Original Date: 
March 1992
Revised Date: 
August 2003
  • Reverse narcotic induced depression, opioid intoxication
  • IV direct: over 3 - 5 minutes
  • IM/ETT in emergency
  • Opioid intoxication: 0.1 - 0.2 mg/kg/dose; repeat Q2-3 minutes PRN
  • Opioid-induced depression: 0.01 - 0.02 mg/kg/dose; repeat Q2-3 minutes PRN
Side Effects: 
  • CVS: tachycardia, hypertension
  • Other: irritability
Parameters to Monitor: 
  • RR
  • Neurologic status

- Solutions Compatible: 0.9% NaCl, D5W

Incompatible: Do NOT mix with any other drugs


  • Contraindications: Acute abstinence syndrome in infants of opioid dependent mothers

-Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 9th-11th Editions. Hudson: Lexi-Comp Inc.; 2002-2004.

-Roy R, Griffiths K, editors. The formulary-The Hospital for Sick Children. 21st-22nd Editions. Toronto: Department of Pharmacy; 2002-2004

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