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Neonatal Drug Therapy Manual |
Naloxone
Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.
Indications:
- Reverse narcotic induced depression, opioid intoxication
Administration:
- IV direct: over 3 - 5 minutes
- IM/ETT in emergency
Dosage:
- Opioid intoxication: 0.1 - 0.2 mg/kg/dose; repeat Q2-3 minutes PRN
- Opioid-induced depression: 0.01 - 0.02 mg/kg/dose; repeat Q2-3 minutes PRN
Side Effects:
- CVS: tachycardia, hypertension
- Other: irritability
Compatibility:
- Solutions Compatible: 0.9% NaCl, D5W
Incompatible: Do NOT mix with any other drugs
Notes:
- Contraindications: Acute abstinence syndrome in infants of opioid dependent mothers
References:
-Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 9th-11th Editions. Hudson: Lexi-Comp Inc.; 2002-2004.
-Roy R, Griffiths K, editors. The formulary-The Hospital for Sick Children. 21st-22nd Editions. Toronto: Department of Pharmacy; 2002-2004
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