Neonatal Drug Therapy Manual

Flucytosine (5-FC)

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Antifungal (Special Access Program)
Original Date: 
March 1992
  • Used in combination with Amphotericin B for the treatment of candida, cryptococcus and aspergillosis infections
  • IV intermittent infusion: over 30 - 60 minutes
  • Preterm infants: 50 - 100 mg/kg/day divided Q12-24H
  • Term infants: 50 - 150 mg/kg/day divided Q6H

Dosage adjustment required in renal impairment.  Refer to available references or clinical pharmacist for dosage adjustment

Side Effects: 
  • GI: vomiting, diarrhea, enterocolitis
  • Hematology: bone marrow depression-related to serum drug concentrations > 100 mg/L
  • Hepatic: increased liver function tests
Parameters to Monitor: 
  • Therapeutic drug levels:
    •  Peak (60 minutes after end of infusion): 50 - 100 mg/L
  • CBC, platelet count
  • Renal function: urine output, serum creatinine, urea

- Solutions Compatible: D5W or 0.9 NaCl

Incompatible: do not mix with other drugs/solutions

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