Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Original Date: 
February 2009
Revised Date: 
February 2021
  • Treatment of ventricular and supraventricular tachyarrhythmias
  • PO
  • 2 - 5 mg/kg/day divided Q8h
    • Allow 2-3 days between dosage increments to achieve new steady-state and to monitor clinical response, heart rate and QTc intervals

Dosage adjustment required in renal impairment. Refer to available references or clinical pharmacist for dosage adjustment.

Side Effects: 
  • CVS: bradycardia, proarrhythmias (SA block, AV block, Torsades de pointes), prolongation of QTc interval, hypotension
  • Dermatologic: rash
  • Endocrine and metabolic: hypoglycemia predominantly in type-1 diabetics
  • Respiratory: dyspnea
Parameters to Monitor: 
  • Daily ECG for 3 days at inititation, and until stable dosing achieved to measure QTc. Monitor heart rate, blood pressure, renal function, serum potassium and magnesium
  • Serum glucose: consider blood glucose monitoring q6h for the first 24-48 hours following  initiation/dose titration.  Blood glucose ac feeds and/or  1-2 hours post-dose. 
Reconstitution and Stability: 





- Lau E. (Editor). Drug Handbook and Formulary - The Hospital for Sick Children 2020 Toronto: lexi-Comp Inc; 2020

- Taketomo CK, Hodding JH, Kraus DM. Pediatric & Neonatal Dosage Handbook 22nd edition. Hudson: Lexi-Comp Inc: 2015

- Läer S, Elshoff JP, Meibohm B, Weil J, Zhang W, Hulpke-Wette M, Development of a Safe and Effective Pediatric Dosing Regimen for Sotalol Based on Population Pharmacokinetics and Pharmacodynamics in Children with Supraventicular Tachycardia. J Am Coll Cardiol. 2005; 46: 1322-1330

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