||Neonatal Drug Therapy Manual
Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.
- Treatment/Prevention of Metabolic Bone Disease, Osteopenia of Prematurity, Rickets of Prematurity.
- Calcium and phosphate must not be given at the same time as they may precipitate. In practice, should be given at alternate feeds
- 20 - 80 mg/kg/day divided Q 6-12H
- Initiate at a dose of 20 mg/kg/day (divided Q12H) to minimize side effects
**Doses are expressed in elemental calcium
Parameters to Monitor:
- Serum calcium, phosphate, alkaline phosphatase
Reconstitution and Stability:
- 20 mg elemental calcium = 0.5 mmol of elemental calcium
- Abrams SA. Management of neonatal bone health. In: UpToDate, Basow, DS (Ed), UpToDate, Waltham, MA, 2014
- Abrams SA, Committee on Nutrition. Calcium and vitamin D requirements of enterally fed preterm infants. Pediatrics 2013; 131:e1676
- Rigo J, Pieltain C, Salle B, Senterre J. Enteral calcium, phosphate and vitamin D requirements and bone mineralization in preterm infants. Acta Paediatr 2007; 96-969
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