Neonatal Drug Therapy Manual

Neostigmine

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Prostigmin
Classification: 
Neuromuscular blocking agent, cholinergic
Original Date: 
June 1996
Indications: 
  • Reversal of neuromuscular blockade of non depolarizing neuromuscular blocking agents such as gallamine, tubocurarine, pancuronium
Administration: 
  • IV direct
Dosage: 
  • Reversal of neuromuscular blockade: 0.02 - 0.08 mg/kg/dose
Side Effects: 
  • CNS: agitation, seizures
  • CVS: bradycardia, hypotension
  • Respiratory: respiratory depression, bronchospasm
Parameters to Monitor: 
  • BP
  • HR
  • RR
Compatibility: 

- Solutions Compatible: D5W, 0.9% NaCl, dextrose-saline combinations

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