- Infection due to susceptible organisms (many Gram (+) cocci except enterococcus and some Gram (-) bacilli)
- Surgical prophylaxis
- IV Direct: over 3 - 5 minutes
- IV intermittent infusion: over 15 minutes
Gestational age & Post-Natal Age | Dose | |
< 32 weeks GA | PNA< 7 days | 50 mg/kg/day divided Q12h |
PNA > 7 days | 75 mg/kg/day divided Q8h | |
> 32 weeks GA | PNA < 7 days | 100 mg/kg/day divided Q12h |
PNA > 7 days | 150 mg/kg/day divided Q8h |
Cardiac Surgery Prophylaxis:
30 mg/kg/dose given in the OR within 60 minutes prior to skin incision. Repeat dose every 6-8 hours during anesthesia.
Following surgery:
- 0-7 days: 30 mg/kg/dose Q12h x 4 doses
- > 7 days: 30 mg/kg/dose Q8h x 6 doses
Dosage adjustment required in renal impairment. Refer to available references or clinical pharmacist for dosage adjustment.
- Hematologic: leukopenia, thrombocytopenia, eosinophilia
- Hepatic: transient elevation of liver enzymes
- Local: phlebitis
- Renal: BUN and serum creatinine elevated
- CBC
- Hepatic function tests
- Renal function (when used in combination with other nephrotoxic drugs)
CHEO:
- Cefazolin 1 g vial (doses < 200 mg)
- Add 9.5 mL SWFI to vial
- Take 4 mL (400 mg) and add to 16 mL D5W
- Final concentration: 20 mg/mL
- Cefazolin 1 g vial (doses > 200 mg)
- Add 9.5 mL SWFI to vial
- Final concentration: 100 mg/mL
TOH:
- Cefazolin 1 g vial
- Add 9.5 mL SWFI to vial
- Take 4 mL (400 mg) and add to 16 mL D5W
- Final concentration: 20 mg/mL
- Solutions Compatible: D5W, D10W, 0.9% NaCl
- Y-site Compatible: calcium gluconate, dexmedetomidine, famotidine, fentanyl, fluconazole, heparin, insulin, KCl, midazolam, milrinone, morphine, pantoprazole, ranitidine, TPN (amino acids/dextrose)
- Incompatible: hydromorphone, tobramycin, vancomycin
-Taketomo CK, Hodding JH, Kraus DM. Pediatric& Neonatal Dosage Handbook 22thEdition. Hudson: Lexi-Comp Inc.; 2015
-American Society on Health-System Pharmacists (ASHP). Handbook on Injectable Drugs. 19th Edition. Bethesda: American Society of Health-System Pharmacists; 2017.
- Murray MT, Corda R, Turcotte R, Bacha E, Saiman L, Krishnamurthy G. Implementing a standardized perioperative antibiotic prophylaxis protocol for neonates undergoing cardiac surgery. Ann Thorac Surg. Sept. 2014; 98 (3): 927-933
- Red Book (2021): Report of the Committee on Infectious Diseases (32nd Edition).