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Neonatal Drug Therapy Manual |
HydrALAZINE
Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.
Indications:
- Treatment of neonatal hypertension
Administration:
- IV direct: over 3 - 5 minutes
- infusion rate not to exceed 5 mg/min or 0.2 mg/kg/min
- IV intermittent infusion: over 15 minutes
Dosage:
- IV: initial: 0.1 - 0.2 mg/kg/dose every 4 - 6 hours up to a max of 0.6 mg/kg/dose
- PO: 0.2 - 1.25 mg/kg/dose every 6 hours
Dose adjustments required in renal impairment. Refer to available references or clinical pharmacist for dosage adjustment
Side Effects:
- CVS: hypotension, tachycardia
- Dermatologic: rash
- GI: nausea, vomiting, diarrhea
- Miscellaneous: SLE-like syndrome
Reconstitution and Stability:
IV direct:
- Hydralazine 20 mg/mL
- Take 1 mL (20 mg) and add to 19 mL of 0.9% NaCl
- Final concentration: 1 mg/mL
Compatibility:
- Solutions Compatible: D10W, 0.9% NaCl, dextrose-saline combinations
- Y-site Compatible: dobutamine, heparin, KCl (up to 40 mEq/L) if mixed with 0.9% NaCl
- Incompatible: ampicillin, furosemide, D5W, hydrocortisone, phenobarbital
References:
- Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 20th Edition. Hudson: Lexi-Comp Inc.; 2013
-Lau E. (Editor). Drug Handbook and Formulary- The Hospital for Sick Children. Toronto: 2013-2014
-Trissel LA. Handbook on Injectable Drugs. 16th Edition. Bethesda: American Society of Health-System Pharmacists; 2003-2005.
-The Childrens Hospital of Eastern Ontario Parenteral Drug Manual. Department of Pharmacy 2009
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