Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Diphteria, Pertussis, Tetanus Toxoid and Inactivated Polio-Haemophilus Influenzae B, Pediacel
Original Date: 
June 1996
Revised Date: 
April 2010
  • Routine childhood immunization
  • IM
  • Shake the vial until a cloudy, uniform suspension results
  • 0.5 mL IM at 2, 4 and 6 months
Side Effects: 
  • Local: pain, redness, swelling and induration at the site of injection
  • Systemic reactions: fever, irritability, drowsiness, prolonged or abnormal crying, convulsions with or without fever
Parameters to Monitor: 


Reconstitution and Stability: 
  • Refrigerate until ready to use


  • Can be co-administered with the following vaccines (at separate injection site): Pneumococcal conjugate vaccine, Hepatitis B, MMR (measles, mumps, rubella)

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