Neonatal Drug Therapy Manual

Ticarcillin/Clavulanic Acid

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Updated September 16, 2014 - 9:06am

Alternate Name(s): 
Timentin
Classification: 
Antibiotic with B-Lactamase Inhibitor
Original Date: 
February 2010
Indications: 
  • Treatment of lower respiratory tract infections due to Stenotrophomonas maltophilia when Septra cannot be used
Administration: 
  • IV intermittent infusion: over 30 - 60 minutes
Dosage: 

- Dosages recommendations are based on ticarcillin component:

  • < 2 kg:
    • 0 - 7 days: 150 mg/kg/day divided Q12h
    • > 7 days: 225 mg/kg/day divided Q8h
  •   > 2 kg:
    • 0 - 7 days: 225 mg/kg/day divided Q8h
    • > 7 days: 300 mg/kg/day divided Q6h

 

Dosage adjustment required in renal and/or hepatic failure. Refer to available references or clinical pharmacist for dosage adjustment.

Side Effects: 
  • Endocrine and metabolic: hypernatremia, hypokalemia
  • GI: diarrhea, nausea, vomiting
  • Hematologic: leukopenia, decreased hemoglobin, inhibition of platelet aggregation, neutropenia, haemolytic anemia, thrombocytopenia
  • Hepatic: elevated ALT, AST, bilirubin
  • Local: thrombophlebitis, pain, swelling
  • Renal: elevated BUN, serum creatinine
Parameters to Monitor: 
  • Serum electrolytes
  • Periodic renal, hepatic and hematologic function tests
Reconstitution and Stability: 

IV intermittent infusion:

  • Ticarcillin/Clavulanate potassium 3.1 g
    • Add 13 mL SWFI. Take 15 mL (3.1 g) and add to 45 mL D5W
    • Final concentration: 50 mg/mL (of ticarcillin)
Compatibility: 

- Solutions Compatible: D5W, 0.9% NaCl

- Y-site Compatible: heparin, insulin, morphine, TPN, KCl

- Incompatible: vancomycin, sodium bicarbonate

Notes: 
  • Separate administration from aminoglycoside (gentamicin, tobramycin) by at least 30 - 60 minutes

The information contained on this website is provided for informational purposes only, as a guide to assist physicians, nurses and other healthcare providers in deciding on the appropriate care required for a particular patient. At all times, physicians, nurses and other healthcare providers must exercise their independent clinical judgment, based on their knowledge, training and experience, taking into account the specific facts and circumstances of each patient, when deciding on the appropriate course of investigation and/or treatment to recommend in a particular clinical situation.

CHEO has made every effort to ensure that the information contained on this website is as current and accurate as possible. However, changes can occur due to ongoing research and the constant influx of new information. Where possible, hospitals and healthcare practitioners should verify the information before acting on it.

Reliance on any information in this website is at the user's own risk. CHEO is not responsible or liable for any harm, loss or other consequences from the use or misuse of the information on this website.